ANALYSIS OF PHAGOCYTIC ACTIVITY OF NEUTROPHILS DURING ATHEROSCLEROSIS

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Abstract

The article presents the results of a comparative analysis of phagocytic activity of neutrophils, isolated from explants of atherosclerotic plaques obtained during endarterectomy in patients with atherosclerosis of the brachiocephalic and femoral arteries and peripheral blood neutrophils of the same patients. Phagocytic activity of neutrophils in atherosclerotic plaques was found to be statistically significantly reduced. We assume that the depletion of the functional ability of neutrophils in the composition of atherosclerotic plaques is associated with chronic inflammation in the intima of vessels in atherosclerosis.

About the authors

O. Yu. Kilinа

Khakass state University named after N. F. Katanov

Author for correspondence.
Email: fake@neicon.ru

doctor of medical Sciences, Director of Medical-psychological-social Institute, Professor of the Department of internal diseases,

Abakan

Russian Federation

S. V. Dutova

Khakass state University named after N. F. Katanov

Email: fake@neicon.ru

doctor of science, associate Professor, acting head of the Department of fundamental medicine and hygiene of Medical, psychological and social Institute,

Abakan

Russian Federation

Yu. V. Saranchina

Khakass state University named after N. F. Katanov

Email: fake@neicon.ru

PhD, associate Professor of the Department of fundamental medicine and hygiene,

Abakan

Russian Federation

T. A. Matrosova

Khakass state University named after N. F. Katanov

Email: fake@neicon.ru

student of Medical-psychological-social Institute,

Abakan

Russian Federation

N. G. Pol’shcha

Khakass state University named after N. F. Katanov

Email: fake@neicon.ru

associate Professor in the Department of internal diseases,

Abakan

Russian Federation

T. S. Kulakova

Khakass state University named after N. F. Katanov

Email: fake@neicon.ru

post-graduate student of the Department of General professional disciplines,

Abakan

Russian Federation

N. V. Chanarin

Khakass state University named after N. F. Katanov

Email: fake@neicon.ru

PhD, associate Professor of the Department of General professional disciplines,

Abakan

Russian Federation

P. I. Shandakov

Republican clinical hospital named after G. YA. Remishevskaya

Email: fake@neicon.ru

PhD, head of the Department of vascular surgery,

Abakan

Russian Federation

References

  1. Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol, 2008, 8, 802–815.
  2. Xue-Mei L, Jie Ch, Dai Xuan, Xiao-Xing L, ChunLin H, Yu-Jie L. Changes in CD4+CD25+ Tregs in the pathogenesis of atherosclerosis in ApoE-/- mice. Exp Biol Med (Maywood), 2017, 242(9), 918–925.
  3. Sivalingam Z., Larsen S. B., Grove E. L., Hvas A. M., Kristensen S.D., Magnusson N. E. Neutrophil gelatinase-associated lipocalin as a risk marker in cardiovascular disease(Review). Clinical Chemistry and Laboratory Medicine, 2017, 56(1), 5–18.
  4. Pertiwi K.R., van der Wal A.C., Pabittei D.R., Mackaaij C., van Leeuwen M.B., Li X, de Boer O. J. Neutrophil кxtracellular traps participate in all different types of thrombotic and haemorrhagic complications of coronary atherosclerosis. Thrombosis and Haemostasis, 2018, 118(6), 1078–87. 5. Hoyer F. F., Nahrendorf M. Neutrophil contributions to ischaemic heart disease. Eur Heart J, 2017, 3, 465–472.

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Copyright (c) 2019 Kilinа O.Y., Dutova S.V., Saranchina Y.V., Matrosova T.A., Pol’shcha N.G., Kulakova T.S., Chanarin N.V., Shandakov P.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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