Email this article TUMOR NECROSIS FACTOR RECEPTORS IN PATIENTS WITH ACTIVE PULMONARY TUBERCULOSIS
- Authors: Kireev F.D.1, Alshevskaya A.A.1, Laushkina Z.A.2, Sennikov S.V.1,3
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Affiliations:
- Federal State Budgetary Scientific Institution «Research Institute of Fundamental and Clinical Immunology»
- Federal State Budgetary Institution «Novosibirsk Research Institute of Tuberculosis, Ministry of Health of Russian Federation»
- Novosibirsk State University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 302-304
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/129
- DOI: https://doi.org/10.31857/S102872210006608-3
- ID: 129
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Abstract
Tumor necrosis factor (TNF) is a key cytokine in the immune response against Mycobacterium tuberculosis (M. tuberculosis). TNF can exhibit its biological eff ects in the presence of a suffi cient number of specifi c receptors on cells – types 1 and 2 membrane receptors (TNFR1 and TNFR2). The objective of this research was to study the diff erences in TNFR expression in patients with active pulmonary tuberculosis (aPTB) in comparison with the parameters of healthy individuals. Expression levels of TNFR1/2 on peripheral blood mononuclear cells (PBMCs) were analysed by fl ow cytometry. TNF and its types 1 and 2 soluble receptors (sTNFR1 and sTNFR2) levels were measured by enzyme-linked immunosorbent assay (ELISA). TNFR1 expression on PBMCs in aPTB patients was increased compared to healthy donors. sTNFR levels were lower in pulmonary tuberculosis patients. Data received suggest that TNF receptors play an important role in the immunopathogenesis of active pulmonary tuberculosis.
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About the authors
F. D. Kireev
Federal State Budgetary Scientific Institution «Research Institute of Fundamental and Clinical Immunology»
Author for correspondence.
Email: fake@neicon.ru
Junior Researcher, Laboratory of Molecular Immunology,
Novosibirsk
Russian FederationA. A. Alshevskaya
Federal State Budgetary Scientific Institution «Research Institute of Fundamental and Clinical Immunology»
Email: fake@neicon.ru
MD, Researcher, Laboratory of Molecular Immunology,
Novosibirsk
Russian FederationZ. A. Laushkina
Federal State Budgetary Institution «Novosibirsk Research Institute of Tuberculosis, Ministry of Health of Russian Federation»
Email: fake@neicon.ru
MD, Doctor, 1st Tuberculosis Pulmonary Department,
Novosibirsk
Russian FederationS. V. Sennikov
Federal State Budgetary Scientific Institution «Research Institute of Fundamental and Clinical Immunology»;Novosibirsk State University
Email: sennikov_sv@mail.ru
MD, Head of the Laboratory of Molecular Immunology;
Senior Lecturer, Department of Clinical Biochemistry,
Novosibirsk
Russian FederationReferences
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- Keeton R., Allie N., Dambuza I., Abel B., Hsu N. J., Sebesho B., Randall P., Burger P., Fick E., Quesniaux V. F., Ryffel B., Jacobs M. Soluble TNFRp75 regulates host protective immunity against Mycobacterium tuberculosis. J Clin Invest. 2014, 124(4), 1537–1551.
- Sennikov S. V., Alshevskaya A. A., Zhukova J., Belomestnova I., Karaulov A. V., Lopatnikova J. A. Expression density of receptors as a potent regulator of cell function and property in health and pathology. Int Arch Allergy Immunol. 2019, 178(2), 182–191.
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