Email this article FLOW CYTOMETRIC ANALYSIS EXPRESSION MARKERS OF ACTIVATION ON CD4 T-LYMPHOCYTES AT RHEUMATOID ARTHRITIS
- Authors: Kostolomova E.G.1,2, Suhovej U.G.1, Unger I.G.1, Akuneeva T.V.1, Krivonosova O.A.2, Zenkova T.V.2, Makeeva O.V.2, Shvets O.J.2
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Affiliations:
- «Tyumen filial of the Institute Clinical Immunology»
- FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation
- Issue: Vol 22, No 2-1 (2019)
- Pages: 332-334
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/139
- DOI: https://doi.org/10.31857/S102872210006618-4
- ID: 139
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Abstract
In research, it is studied coexpression CD69 and HLA-DR on sinovial T-lymphocytes at rheumatoid arthritis. The received results allow to assume, that in sinovial fluid there is a constant activation of T-cell that leads expression a marker CD69 on a surface chronically it stimulates lymphocytes only at the location the inflammation.
About the authors
E. G. Kostolomova
«Tyumen filial of the Institute Clinical Immunology»;FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation
Author for correspondence.
Email: lenakost@mail.ru
PhD (Biology), the assistant to faculty of pathological physiology,
Tyumen
Russian FederationU. G. Suhovej
«Tyumen filial of the Institute Clinical Immunology»
Email: fake@neicon.ru
MD (Medicine), Professor, Director,
Tyumen
Russian FederationI. G. Unger
«Tyumen filial of the Institute Clinical Immunology»
Email: fake@neicon.ru
PhD (Medicine), leading research associate,
Tyumen
Russian FederationT. V. Akuneeva
«Tyumen filial of the Institute Clinical Immunology»
Email: fake@neicon.ru
senior research associate,
Tyumen
Russian FederationO. A. Krivonosova
FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation
Email: fake@neicon.ru
student,
Tyumen
Russian FederationT. V. Zenkova
FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation
Email: fake@neicon.ru
student,
Tyumen
Russian FederationO. V. Makeeva
FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation
Email: fake@neicon.ru
student,
Tyumen
Russian FederationO. J. Shvets
FSBEI of Higher Education «Tyumen state medical university» of the Ministry of Healthcare of Russian Federation
Email: fake@neicon.ru
student,
Tyumen
Russian FederationReferences
- Veale D. J. Cellular and molecular perspectives in rheumatoid arthritis / D. J. Veale, C. Orr, U. Fearon // Semin Immunopathol. – 2017. doi: 10.1007/s00281-017-0633-1.
- Moore T. L. Immune Complexes in Juvenile Idiopathic Arthritis / T. L. Moore // Front Immunol. – 2016. – Vol.7. – P. 177. doi: 10.3389/fimmu.2016.00177.
- Shipkova M., Wieland E. Surface markers of lymphocyte activation and markers of cell proliferation. Clin.Chim. Acta., 2012, vol. 413, no. 17–18, pp. 1338–1349.
- Wieland E., Shipkova M. Lymphocyte surface molecules as immune activation biomarkers // Clin Biochem. – 2016. – Vol.49(4–5). – P. 347–354.
- Чередеев Н. А., Горлина Н. К., Козлов И. Г. CDмар ке ры в практике клинико-диагностических лабораторий // Клиническая лабораторная диагностика. – 1999, № 6. С. 24–31.
- Yamada H., Nakashima Y., Okazaki K., Mawatari T., Fukushi J., Oyamada A., Fujimura K., Iwamoto Y., Yoshikai Y. Preferential Accumulation of Activated Th1 Cells Not Only in Rheumatoid Arthritis But Also in Osteoarthritis Joints // The Journal of Rheumatology. – 2011. – Vol. 38, № 8. – P. 1569–1575.
- Testi R., Pulcinelli F. M., Cifone M. G., Trotta R., Torelli G., Demaria R., Frati L., Santoni A. Signaling in T lymphocytes: a possible accessory pathway initiated at the CD69 receptor. J. Immunol. Res. 1992, 4, 111–117.
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