Email this article THE ANALYSIS OF PERIPHERAL BLOOD CYTOKINES IN WOMEN WITH RECURRENT SPONTANEOUS ABORTION
- Authors: Kroshkina N.V.1, Kust A.V.1, Kozelkova E.V.1
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Affiliations:
- Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» of the Ministry of Health of Russia
- Issue: Vol 22, No 2-1 (2019)
- Pages: 344-346
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/143
- DOI: https://doi.org/10.31857/S102872210006622-9
- ID: 143
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Abstract
The level of IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-18, IL-21, IL-22, IL-23, IL-27, IFNγ, TNFα, GM-CSF in the peripheral blood of women with recurrent spontaneous abortion and uncomplicated pregnancy was investigated at 5–12 weeks of gestation. It was established, that the serum level of IL-1β, IL-22, IL-23 and IL-27 in women with habitual abortion increased, and the tendency to the elevation of serum level of IL-10 и IL-13 was seen.
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About the authors
N. V. Kroshkina
Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» of the Ministry of Health of Russia
Email: fake@neicon.ru
PhD, researcher of the laboratory of clinical immunology,
Ivanovo
Russian FederationA. V. Kust
Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» of the Ministry of Health of Russia
Author for correspondence.
Email: niimid.immune@mail.ru
postgraduate Student of the laboratory of clinical immunology,
Ivanovo
Russian FederationE. V. Kozelkova
Federal State Budget Establishment «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» of the Ministry of Health of Russia
Email: fake@neicon.ru
postgraduate Student of the Department of Obstetrics and Gynecology, Neonatology, Anesthesiology and Reanimatology,
Ivanovo
Russian FederationReferences
- Zhao X., Jiang Y., Wang L., Li Z., Li Q., Feng X. Advances in understading the immune imbalance between T-lymphocyte subsets and NK cells in recurrent spontaneous abortion. Geburtshilfe Fraunheilkd. 2018, 78(7), 677–683.
- Southcombe J., Tannetta D., Redman C., Sargent I. The immunomodulatory role of syncytiotrophoblast microvesicles. PLos One. 2011, 6(5): e20245.
- Батрак Н. В., Малышкина А. И., Сотникова Н. Ю., Крошкина Н. В. Урогенитальная инфекция как фактор риска рецидивирующих потерь беременности. Российский иммунологический журнал. 2015, 9(18); 1(1), 19–20. [Batrak N. V., Malyshkina A. V., Sotnikova N. Yu., Kroshkina N. V. Urogenital infection as risk factor of recurrent miscarriage. Russian Journal of Immunology. 2015, 9(18); 1(1), 19–20].
- Caprioli F., Sarra M., Caruso R., Stolfi C., Fina D., Sica G., MacDonald T. T., Pallone F., Monteleone G. Autocrine regulation of IL-21 production in human T lymphocytes. J Immunol. 2008, 180(3), 1800–1807.
- Zotos D., Coquet J. M., Zhang Y., Light A., D’Costa K., Kallies A., Corcoran L. M., Godfrey D. I., Toellner K. M., Smyth M. J., Nutt S. L., Tarlinton D. M. IL-21 regulates germinal center B cell diff erentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med. 2010, 207(2), 365–378.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).