Email this article THE ROLE OF NEUTROFILS IN THE PATHOGENESIS OF PREECLAMPSIA
- Authors: Kudryashova A.V.1, Panova I.A.1, Rokotyanskaya E.A.1
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Affiliations:
- Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» the Ministry of Health of the Russian Federation
- Issue: Vol 22, No 2-1 (2019)
- Pages: 350-352
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/145
- DOI: https://doi.org/10.31857/S102872210006624-1
- ID: 145
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Abstract
The aim of the work was to assess the nature of changes in the functional activity of neutrophils in women with preeclampsia and to identify their significance in the development of hypertension and proteinuria. For neutrophils of women with preeclampsia, the following were observed: increased levels of CD11b+, CD31+, CD49b, TLR4+, AnnexinV+PI+, IFNγ+, Granzyme B+, NBT-active cells, serum G-CSF, IL-8, IFNγ and Fractalkine; high level of MMP-9 synthesis; decreased levels of CD95+, CX3CR1+, CD62L+ and CD99+ cells. Correlation was noted between: the level of CD62L+, CD99+, CXCR1+ neutrophils, serum IL-8 and impaired elastic properties of blood vessels; CX3CR1+ neutrophil level and mean arterial pressure and proteinuria in a single portion of urine.
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About the authors
A. V. Kudryashova
Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» the Ministry of Health of the Russian Federation
Author for correspondence.
Email: niimid.immune@mail.ru
ВD, senior researcher of the laboratory of clinical immunology,
Ivanovo
Russian FederationI. A. Panova
Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
MD, assistant professor, head of Department of obstetrics and gynecology,
Ivanovo
Russian FederationE. A. Rokotyanskaya
Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
PhD, assistant Professor of the Department of Obstetrics and Gynecology,
Ivanovo
Russian FederationReferences
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