Email this article IMMUNOENDOCRINE DISTURBANCES IN PATIENTS WITH SCHIZOPHRENIA IN THE PROCESS OF ANTIPSYCHOTIC THERAPY
- Authors: Lobacheva O.A.1, Vetlugina T.P.1, Kornetova E.G.1, Semke A.V.1
-
Affiliations:
- Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences (Mental Health Research Institute of Tomsk NRMC)
- Issue: Vol 22, No 2-1 (2019)
- Pages: 374-376
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/153
- DOI: https://doi.org/10.31857/S102872210006632-0
- ID: 153
Cite item
Full Text
Abstract
Study of dynamics of immunoendocrine parameters in 27 patients with schizophrenia has shown that acute period of schizophrenia after long-term maintenance treatment with quetiapine is accompanied by immune-hormonal imbalance characterized by cellular immune deficit, increase in the concentration thyroid-stimulating hormone, reduction in thyroid hormones and prolonged elevation of the level of cortisol in blood. The obtained data will allow further revealing the criteria of personalized approach to treatment of patients with possible joining additional pharmacotherapy from the first days of the admission of patients in the hospital.
Keywords
About the authors
O. A. Lobacheva
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences (Mental Health Research Institute of Tomsk NRMC)
Author for correspondence.
Email: oalobacheva@mail.ru
MD, lead researcher of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology,
Tomsk
Russian FederationT. P. Vetlugina
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences (Mental Health Research Institute of Tomsk NRMC)
Email: fake@neicon.ru
D. Sc., Prof., lead researcher of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology, Head of the Department of Biological Psychiatry and Narcology,
Tomsk
Russian FederationE. G. Kornetova
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences (Mental Health Research Institute of Tomsk NRMC)
Email: fake@neicon.ru
MD., lead researcher of the Endogenous Disorders Department,
Tomsk
Russian FederationA. V. Semke
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences (Mental Health Research Institute of Tomsk NRMC)
Email: fake@neicon.ru
MD., Prof., Head of the Endogenous Disorders Department,
Tomsk
Russian FederationReferences
- Теоретические и практические аспекты психонейроэндокринологии. / Под ред. проф. Л. Н. Горобец. М.: 2012, 40–57.
- Müller N. Immunological aspects of the treatment of depression and schizophrenia. Dialogues Clin Neurosci. 2017, 19(1), 55–63.
- Никитина В. Б., Лобачева О. А., Ветлугина Т. П., Аксенов М. М., Лебедева В. Ф. Нейроиммуноэндокринные нарушения при психических расстройствах и болезнях зависимости. Сибирский вестник психиатрии и наркологии. 2018, 2(99), 45–55.
- Мосолов С. Н., Цукарзи Э. Э., Капилетти С. Г. Антипсихотическая фармакотерапия шизофрении: от научных данных к клиническим рекомендациям. В кн.: Биологические методы терапии психических расстройств / Ред. Мосолов С. Н. Доказательная медицина – клинической практике. Москва, 2012, 11–61.
- Ветлугина Т. П., Лобачева О. А., Альперина Е. Л., Жукова Е. Н., Семке А. В., Никитина В. Б., Чейдо М. А., Идова Г. В. Клинико-экспериментальные исследования иммуномодулирующего эффекта амисульприда. Вестник Российской академии медицинских наук. 2012, 12(67), 13–17.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).