Email this article REGULATORY T-CELLS IN ACUTE ISCHEMIC STROKE AND THEIR RELATION WITH INFLAMMATORY RESPONSE AND DEVELOPMENT OF INFECTIOUS COMPLICATIONS
- Authors: Morozov S.A.1, Pronkina N.V.1, Starostina N.M.1, Leplina O.Y.1, Ostanin A.A.1, Shtobbe A.A.2, Chernykh E.R.1
-
Affiliations:
- Research Institute of Fundamental and Clinical Immunology
- City Clinical Hospital № 1
- Issue: Vol 22, No 2-1 (2019)
- Pages: 423-425
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/171
- DOI: https://doi.org/10.31857/S102872210006918-4
- ID: 171
Cite item
Full Text
Abstract
The study has demonstrated a signifi cant increase in percentage of circulating CD4+CD25hi regulatory T cells and a decrease in Th1 (CD4+IFNγ+ N cells), as well as elevated leukocyte count, neutrophil-tolymphocyte ratio and CRP level during the first 24–48 hours after onset of ischemic stroke (IS). O note, patients with poststroke infection had less pronounced increase in CD4+CD25hi T-cells and the decrease in CD4+IFNγ+ T lymphocytes, while inflammatory response was significantly higher than in the opposite group. The largest difference between groups was observed when assessing the ratio of CD4+IFNγ+ and CD4+CD25hi T cells. The ratio of CD4+IFNγ+/ CD4+CD25hi in patients with infections was 3 times higher than in the group without infectious complications, correlated with the concentration of CRP (R = 0.54; p = 0.02) and the value of ratio > 1.14 allowed to predict infection with a specificity of 85.7% and a sensitivity of 68.8%.
About the authors
S. A. Morozov
Research Institute of Fundamental and Clinical Immunology
Author for correspondence.
Email: el-gorra@mail.ru
post-graduate student, laboratory of cellular immunotherapy,
Novosibirsk
Russian FederationN. V. Pronkina
Research Institute of Fundamental and Clinical Immunology
Email: fake@neicon.ru
Head of laboratory of clinical immunology,
Novosibirsk
Russian FederationN. M. Starostina
Research Institute of Fundamental and Clinical Immunology
Email: fake@neicon.ru
PhD, Head of Department of immunology,
Novosibirsk
Russian FederationO. Y. Leplina
Research Institute of Fundamental and Clinical Immunology
Email: fake@neicon.ru
MD, Leading Researcher,
Novosibirsk
Russian FederationA. A. Ostanin
Research Institute of Fundamental and Clinical Immunology
Email: fake@neicon.ru
MD, Chief Researcher,
Novosibirsk
Russian FederationA. A. Shtobbe
City Clinical Hospital № 1
Email: fake@neicon.ru
PhD, Head of Department of neurilogy,
Novosibirsk
Russian FederationE. R. Chernykh
Research Institute of Fundamental and Clinical Immunology
Email: fake@neicon.ru
MD, Corresponding Member of the Russian Academy of Sciences, Head of laboratory of cellular immunotherapy,
Novosibirsk
Russian FederationReferences
- Yan J., Read S.J., Henderson R.D., Hull R., O’Sullivan J., McCombe P., Greer J. Frequency and function of regulatory T cells after ischaemic stroke in humans. Journal of Neuroimmunology. 2012, 243; 1–2, 89–94.
- Liesz A., Kleinschnitz C. Regulatory T сells in Poststroke Immune Homeostasis. Transl Stroke Res. 2016, 7; 4, 313–321.
- Saino O., Taguchi A., Nakagomi T., Nakano-Doi A., Kashiwamura S., Doe N., Nakagomi N., Soma T., Yoshikawa H., Stern D., Okamura H. Immunodefi ciency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke. J. Neurosci Res, 2010, 88, 2385–2389.
- Zouggari Y., Ait-Oufella H., Waeckel L., Vilar J., Loinard C., Cochain C., Recalde A., Duriez M., Levy B., Lutgens E., Silvestre J. Regulatory T cells modulate postischemic neovascularization. Circulation. 2009, 120, 1415–1425.
- Shi K., Wood K., Shi F., Wang X, Liu Q. Stroke-induced immunosuppression and poststroke infection. Stroke Vasc Neurol. 2018, 3, 34–41.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).