CYTOKINE DYNAMICS AS A RESULT OF PHYTO-FLAVANOID EXPOSURE IN WOMEN WITH UTERINE MYOMA

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Abstract

A study was conducted to study the effectiveness of the use of the herbal preparation Bioflazid in 28 women with a simple form of uterine fibroids. The levels of pro- (IL-6, IL-8, IL-18, and TNFα) and anti-inflammatory (IL-10) cytokines in serum were studied. Positive dynamics of both clinical parameters and levels of studied cytokines was revealed.

About the authors

N. S. Narzullaeva

Bukhara Medical Institute named after Abu Ali ibn Sino

Author for correspondence.
Email: fake@neicon.ru

ass. of Department of Obstetrics and Gynecology,

Bukhara

Uzbekistan

D. A. Musakhodzhaeva

Institute of Human Immunology and Genomics, Academy of Sciences of the Republic of Uzbekistan

Email: dilym@mail.ru

DSc, Head of the Laboratory of Immunology of Reproduction,

Tashkent

Uzbekistan

M. M. Abdurakhmanov

Bukhara Medical Institute named after Abu Ali ibn Sino

Email: fake@neicon.ru

DSc., professor,

Bukhara

Uzbekistan

G. A. Ikhtiyarova

Bukhara Medical Institute named after Abu Ali ibn Sino

Email: fake@neicon.ru

PhD, Department of Obstetrics and Gynecology,

Bukhara

Uzbekistan

References

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  2. Shushan A., Ben-Bassat H., Mishani E., Laufer N., Klein B. Y., Rojansky N. Inhibition of leiomyoma cell proliferation in vitro by genistein and the protein tyrosine kinase inhibitor TKS050. Fertility and Sterility. 2007; 87: 1: 127–135. https://doi.org/10.1016/j.fertnstert.2006.05.056
  3. Miyake A., Takeda T., Isobe A., Wakabayashi A., Nishimoto F., Morishige K.I., Kimura T. Repressive effect of the phytoestrogen genistein on estradiol-induced uterine leiomyoma cell proliferation. Gynecological Endocrinology. 2009; 25: 6: 403–409. https://doi.org/10.1080/09513590902730804
  4. Di X., Andrews D. M., Tucker C. J., Yu L., Moore A. B., Zheng X., Dixon D. A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. Experimental and Molecular Medicine. 2012; 44: 4: 281– 292. https://doi.org/0,3858/emm.2012.44.4.024
  5. Castro L., Gao X., Moore A. B., Yu L., Di X., Kissling G. E., Dixon D. High Concentration of Genistein Induces Cell Death in Human Uterine Leiomyoma Cells by Autophagy. Expert OpinEnviron Biol. 2016; 5: Suppl 1. https://dx.doi.org/10.4172/2325-9655.S1-003

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Copyright (c) 2019 Narzullaeva N.S., Musakhodzhaeva D.A., Abdurakhmanov M.M., Ikhtiyarova G.A.

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