EFFECTS OF CARBOPLATIN WITH CUCURBIT[7]URIL ON SUBPOPULATION COMPOSITION AND PROLIFERATIVE ACTIVITY OF LYMPHOCYTES IN VITRO

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Abstract

It is known that the use of delivery systems can reduce the toxicity of platinum compounds without losing a high therapeutic effect. In this work, the immunotoxic effect of carboplatin when co-added with cucurbit[7]uril was investigated, including the effect on the subpopulation composition of lymphocytes and their proliferative activity in vitro.

About the authors

E. A. Pashkina

FSBSI “Research Institute of Fundamental and Clinical Immunology”;
Novosibirsk State Medical University

Author for correspondence.
Email: pashkina.e.a@yandex.ru

PhD, Researcher, Clinical Immunopathology Laboratory;

Assistant of the Department of Clinical Immunology at the Medical Faculty,

Novosibirsk

Russian Federation

A. A. Aktanova

Novosibirsk State Medical University

Email: fake@neicon.ru

six-year student of the Faculty of Medicine and Prevention of the specialty of Medical Biophysics,

Novosibirsk

Russian Federation

A. A. Ermakov

Novosibirsk State Medical University

Email: fake@neicon.ru

six-year student of the Faculty of Medicine and Prevention of the specialty of Medical Biophysics,

Novosibirsk

Russian Federation

N. Yu. Knauer

FSBSI “Research Institute of Fundamental and Clinical Immunology”

Email: fake@neicon.ru

PhD student, Clinical Immunopathology Laboratory,

Novosibirsk

Russian Federation

I. V. Mirzaeva

Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

PhD, Researcher, Laboratory of Condensed Matter Physical Chemistry, 

Novosibirsk

Russian Federation

E. A. Kovalenko

Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

PhD, Researcher, Laboratory of cluster and supramolecular chemistry,

Novosibirsk

Russian Federation

References

  1. Wheate N. J. Improving platinum (II)-based anticancer drug delivery using cucurbit [n] urils. Journal of inorganicbiochemistry. 2008, 102, 2060–2066.
  2. Mirzaeva I. V., Moroz N. K., Andrienko I. V., Kovalenko E. A. Interaction between carboplatin and cucurbit[7]uril studied by means of multinuclear NMR spectroscopy and DFT calculations J. Mol. Struct. 2018, 1163, 68–76.
  3. Актанова А. А., Ермаков А. А., Пашкина Е. А. Сравнительный анализ противоопухолевого и иммунотоксического действия комплекса кукурбит[7] урила с карбоплатином. Российский иммунологический журнал. 2018, 12(21), 595–597.

Copyright (c) 2019 Pashkina E.A., Aktanova A.A., Ermakov A.A., Knauer N.Y., Mirzaeva I.V., Kovalenko E.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


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