Email this article EVALUATION OF VASCULAR ENDOTHELIAL FACTORS IN WOMEN WITH SELECTIVE DELAY OF FETUS GROWTH DURING MONOCHORIAL PREGNANCY
- Authors: Remizova I.I.1, Chistyakova G.N.1, Aitov A.E.1
-
Affiliations:
- Ural Scientific Research Institute of Maternity and Child Care
- Issue: Vol 22, No 2-1 (2019)
- Pages: 489-491
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/192
- DOI: https://doi.org/10.31857/S102872210006940-9
- ID: 192
Cite item
Full Text
Abstract
The urgency of the problem of monochorial multiple pregnancy is due to the significant frequency of development of selective intrauterine growth-restricted (sIUGR) of the fetus.
Objective: To evaluate the features of angiogenesis in women with fetal sIUGR during monochorial pregnancy. 46 pregnant women with monochorial diamniotic twins were examined: 21 women with fetal sIUGR and 25 women without gestational complications. It has been established that the implementation of fetal sIUGR in monochorial pregnancy is caused by an imbalance of the main regulators of angiogenesis, endothelial dysfunction and a decrease in the number of endothelial progenitor cells, which leads to a violation of the stabilization and integrity of the vascular endothelium.
About the authors
I. I. Remizova
Ural Scientific Research Institute of Maternity and Child Care
Author for correspondence.
Email: RemizovaII@yandex.ru
Ph.D., Senior Researcher Department of Immunology, Microbiology, Pathomorphology and Cytodiagnostics,
Yekaterinburg
Russian FederationG. N. Chistyakova
Ural Scientific Research Institute of Maternity and Child Care
Email: omm@niiomm.ru
MD, Professor, Head of the Department of Immunology, Microbiology, Pathomorphology and Cytodiagnostics,
Yekaterinburg
Russian FederationA. E. Aitov
Ural Scientific Research Institute of Maternity and Child Care
Email: omm@niiomm.ru
correspondence postgraduate student,
Yekaterinburg
Russian FederationReferences
- Coutinho Nunes F., Domingues A. P., Tavares M Vide, Belo A., Ferreira C., Fonseca E. and Moura P. Monochorionic versus dichorionic twins: Are obstetric outcomes always diff erent? J Obstet Gynaecol. 2016, 36(5), 598–601.
- Vlašínová I., Hruban L., Janků P., Gerychová R., Ventruba P., Ťápalová V., Hodická Z. Specifi c placental complications of monochorionic diamniotic twins born after 24 weeks of pregnancies – restrospective analysis. Ceska Gynekol. 2015, 80(3),189–95.
- Чистякова Г. Н., Ремизова И. И., Каюмова А. В., Данькова И. В., Мелкозерова О. А. Маркеры дисфункции эндотелия в прогнозировании плацентарной недостаточности с ранних сроков беременности, индуцированной вспомогательными репродуктивными технологиями. Проблемы репродукции. 2017, 6, 11–15.
- Yzydorczyk C., Armengaud J.B., Peyter A.C., Chehade H., Cachat F., Juvet C., Siddeek B., Simoncini S., Sabatier F., Dignat-George F., Mitanchez D., Simeoni U. Endothelial dysfunction in individuals born after fetal growth restriction: cardiovascular and renal consequences and preventive approaches. J. Dev. Orig. Health. Dis. 2017, 8(4), 448–464.
- Attar A., Monabati A., Parsanezhad M.E.. Endothelial progenitor cell subsets and preeclampsia: Findings and controversies. J Chin Med Assoc. 2017, 80(10), 615–622.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).