EXPERIMENTAL MICE SEPSIS MODELS: ADVANTAGES AND PITFALLS

Sepsis is studied in vivo by using experimental mice models. The golden standard is the model which utilizes peritonitis induction by cecal ligation and puncture. Lipopolysacharide injection is often used for induction of septic process as well. Currently, the researches discuss disadvantages of these models and poor modeling capability of mice sepsis compared to septic processes which take place in humans. The throughout discussion is present in the article by Cavaillon J. M. “New Approaches to Treat Sepsis: Animal Models Do Not Work” [1]. In this review the author questioned the sepsis animal models used nowadays, but he didn’t mentioned the experimental model described by Gonnert F. A. et al. in their work «Characteristics of Clinical Sepsis Refl ected in a Reliable and Reproducible Rodent Sepsis Model». Our review briefl y discusses the advantages of this model compared to the other animal sepsis models.