INVESTIGATION OF NEUTROPHIL MIGRATION VIA LYMPHATIC VESSELS IN THE COURSE OF A. FUMIGATUS-INDUCED INFLAMMATION

Cover Page


Cite item

Full Text

Abstract

Neutrophils are the main eff ector cells that are mediated immune response to exogenous pathogens including opportunistic fungi Aspergillus fumigatus. Neutrophils infi ltrate infl amed tissues and massively die during the fi ght against pathogen. However, in some cases neutrophils survive and migrate to lymphatic vessels to neutralize residual pathogens and activate adaptive immune response. In the present study we characterized the ability of neutrophils to migrate via lymphatic vessels during A. fumigatus conidia-induced infl ammation. As a result, new data about neutrophils migration kinetics to lymphatic vessels and the role of neutrophils in control of fungal spore dissemination in the host organism were obtained.

About the authors

E. L. Bolkhovitina

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Author for correspondence.
Email: alenkash83@gmail.com

JRF Laboratory of Cell Interactions,

Moscow

Russian Federation

A. S. Fedorina

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS;
Moscow Institute of Physics and Technology

Email: fake@neicon.ru

Student, Moscow;

Dolgoprugniy

Russian Federation

A. O. Bogorodskiy

Lomonosov Moscow State University

Email: fake@neicon.ru

PhD student,

Moscow

Russian Federation

A. O. Smirnova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS;
Lomonosov Moscow State University

Email: fake@neicon.ru

Student,

Moscow

Russian Federation

E. N. Chursanova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS;
Moscow Institute of Physics and Technology

Email: fake@neicon.ru

Student, Moscow;

Dolgoprugniy

Russian Federation

A. M. Sapozhnikov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: fake@neicon.ru

Professor, Head of the Laboratory of Cell Interactions, 

Moscow

Russian Federation

V. I. Borshchevskiy

Lomonosov Moscow State University

Email: fake@neicon.ru

PhD, SRF, Laboratory for Advanced Studies of Membrane Proteins,

Moscow

Russian Federation

M. A. Shevchenko

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: fake@neicon.ru

PhD, RF, Laboratory of Cell Interactions,

Moscow

Russian Federation

References

  1. Bogoslowski A., Butcher E. C., Kubes P. Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminating Staphylococcus aureus. Proc Natl Acad Sci USA. 2018;115(10):2449–2454.
  2. Lu T., Kobayashi S. D., Quinn M. T., Deleo F. R. A NET Outcome. Front Immunol. 2012 Dec 5;3:365.
  3. Abadie V., Badell E., Douillard P., Ensergueix D., Leenen P. J., Tanguy M., Fiette L., Saeland S., Gicquel B., Winter N. Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes. Blood. 2005 Sep 1;106(5):1843–50.
  4. Shevchenko M.A., Bogorodskiy A.O., Troyanova N.I., Servuli E. A., Bolkhovitina E. L., Büldt G., Fahlke C., Gordeliy V. I., Gensch T., Borshchevskiy V. I., Sapozhnikov A. M. Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice. J Immunol Res. 2018 Jan 18; 2018:5379085.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Bolkhovitina E.L., Fedorina A.S., Bogorodskiy A.O., Smirnova A.O., Chursanova E.N., Sapozhnikov A.M., Borshchevskiy V.I., Shevchenko M.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies