Email this article MOLECULAR COMPONENT-RESOLVED DIAGNOSTICS FOR CAT ALLERGY IN CHILDREN WITH ALLERGIC RHINITIS
- Authors: Bass E.A.1,2
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Affiliations:
- Federal State Budgetary Institution of Science Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
- State Autonomous Healthcare Institution of Sverdlovsk Region Regional Children’s Clinical Hospital, consultative and diagnostic clinic
- Issue: Vol 22, No 2-1 (2019)
- Pages: 153-155
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/28
- DOI: https://doi.org/10.31857/S102872210006433-1
- ID: 28
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Abstract
Hypersensitivity to cat allergens is a serious clinical problem in many countries because of the high prevalence of these animals. The aim of this study is to assess the spectrum of sensitization to the cat allergen’smolecular components and its role in allergic rhinitis in children. IgE-aB to rFel d 1 were detected in 91.8% of children, to nFel d 2 ‒ in 16.4%, to rFel d 4 ‒ in 43.8% of patients. At the same time ‒ 56.2% of children were monosensitizated to rFel d 1; 27.4% with identifi ed IgE-aB to rFel d 1 and rFel d 4; 8.2% ‒ from IgE-aB to rFel d 1 + nFel d 2 + rFel d 4; and 8.2% ‒ with IgE-aB to nFel d 2 + rFel d 4. Sensitization only to minor allergens did not lead to the development of asthma, but exacerbations of AR in these patients occurred more frequently. To assess the prognosis of the disease and possible reactions to cross-allergens, we recommend component-resolved diagnostics.
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About the authors
E. A. Bass
Federal State Budgetary Institution of Science Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences;State Autonomous Healthcare Institution of Sverdlovsk Region Regional Children’s Clinical Hospital, consultative and diagnostic clinic
Author for correspondence.
Email: bass.ea@yandex.ru
Allergist-immunologist, Consultative and Diagnostic Clinic,
Yekaterinburg
Russian FederationReferences
- Dolgova A. S., Sudina A. E., Cherkashina A. S., Stukolova O. A. Component-resolved microarray analysis of IgE sensitization profi les to Feliscatus major allergen molecules in Russian cat-allergic patients. Scand J Clin Lab Invest. 2018 Feb – Apr;78(1–2):81–86.
- Ukleja-Sokołowska N., Gawrońska-Ukleja E., Żbikowska-Gotz M., Socha E., Lis K., Sokołowski L., Kuźmiński A., and Bartuzi Z. Analysis of feline and canine allergen components in patients sensitized to pets. Allergy Asthma Clin Immunol. 2016; 12: 61.
- Uriarte S. A., Sastre J. Clinical relevance of molecular diagnosis in pet allergy. Allergy. 2016 Jul;71(7):1066–8.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).