GENERATION AND CHARACTERIZATION OF RECOMBINANT ANTIBODY AGAINST THE COMPLEMENT C5a ANAPHYLATOXIN

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Abstract

Monoclonal mouse antibodies were raised against the human C5a anaphylatoxin. In these antibodies, the light- and heavy-chain constant regions were replaced by human IgG constant regions to produce chimeric mouse–human antibodies.

About the authors

A. A. Vasilishina

State Research Institute of Highly Pure Biopreparations

Author for correspondence.
Email: a.a.vasilishna@hpb.spb.ru

MD, Biologist of Laboratory of Protein Biochemistry,

Saint Petersburg

Russian Federation

A. V. Demyanov

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

MD, Head of Laboratory of Immunopharmacology,

Saint Petersburg

Russian Federation

V. S. Monahova

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

Biologist, Laboratory of Protein Biochemistry,

Saint Petersburg

Russian Federation

A. V. Zhakhov

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

Leading Researcher, Laboratory of Protein Biochemistry,

Saint Petersburg

Russian Federation

A. V. Trofimov

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

Group Leader, Laboratory of Protein Biochemistry,

Saint Petersburg

Russian Federation

E. S. Denisenko

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

Project Manager,

Saint Petersburg

Russian Federation

K. A. Nekrasova

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

Deputy Head of R&D Department,

Saint Petersburg

Russian Federation

S. V. Rodin

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

Group Leader, Laboratory of Protein Biochemistry,

Saint Petersburg

Russian Federation

A. S. Simbirtsev

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

RAS Corresponding Member, DMedSci, Professor, Scientific Supervisоr,

Saint Petersburg

Russian Federation

A. M. Ischenko

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

PhD, Head of Laboratory of Protein Biochemistry,

Saint Petersburg

Russian Federation

References

  1. Chunguang Yan, Hongwei Gao. New insights for C5a and C5a receptors in sepsis. Front Immunol. 2012, 5, 197.
  2. Aird W. C. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 2003, 101, 3765–3777.
  3. Peter A. Ward Role of C5 Activation Products in Sepsis. The Scientific World Journal. 2010, 10, 2395– 24022010.

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Copyright (c) 2019 Vasilishina A.A., Demyanov A.V., Monahova V.S., Zhakhov A.V., Trofimov A.V., Denisenko E.S., Nekrasova K.A., Rodin S.V., Simbirtsev A.S., Ischenko A.M.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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