Email this article THE VARIANTS OF DEATH INNATE IMMUNITY CELLS IN CHRONIC OBSTRUCTIVE LUNG DISEASE OBSTRUCTIVE LUNG
- Authors: Zinoviev S.V.1, Plekhova N.G.1, Kondrashova N.M.1
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Affiliations:
- Pacific State Medical University
- Issue: Vol 22, No 2-2 (2019)
- Pages: 772-774
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/296
- DOI: https://doi.org/10.31857/S102872210006703-8
- ID: 296
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Abstract
A morphological and cytochemical study of the oxidative metabolism of cells bronchoalveolar lavage (BAL) patients with varying degrees of severity chronic obstructive pulmonary disease (COPD) was studed. It was established that along with cell necrosis, enucleation of granulocytes and macrophages is determined, which refers to the morphological feature of programmed death by the formation of extracellular traps – NET-osis. Proven correlation between indicators of netosis, changes in the oxidative metabolism of cells and the degrees of severity of COPD.
About the authors
S. V. Zinoviev
Pacific State Medical University
Author for correspondence.
Email: Sinowev@mail.ru
PhD, Senior Researcher, of the Central Research Laboratory,
Vladivostok
Russian FederationN. G. Plekhova
Pacific State Medical University
Email: fake@neicon.ru
Dr, Head of the Central Research Laboratory,
Vladivostok
Russian FederationN. M. Kondrashova
Pacific State Medical University
Email: fake@neicon.ru
PhD, assistant professor at the Institute of Therapy and Instrumental Diagnostics,
Vladivostok
Russian FederationReferences
- Galluzzi L., Maiuri M. C., Vitale I., Zischka H., Castedo M., Zitvogel L., Kroemer G. Cell death modalities: classification and pathophysiological implications. Cell Death Differ. 2007, 14(7):1237–43.
- Wright T. K., Gibson P. G., Simpson J. L., McDonald V. M., Wood L. G., Baines K. J. Neutrophil extracellular traps are associated with inflammation in chronic airway disease // Respirology. 2016 Apr;21(3):467–75.
- Глобальная стратегия диагностики, лечения и профилактики хронической обструктивной болезни легких (пересмотр 2014 г.) / Пер с анг. Под ред. А. С. Белевского. М.: Российское респираторное общество, 2014:92.
- Khan M. A., Philip L. M., Cheung G., Vadakepeedika S., Grasemann H., Sweezey N., Palaniyar N. Front Med (Lausanne). Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis. 2018; 5:19.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).