THE MODEL OF PSORIASIFORM DERMATITIS IN MICE INDUCED BY INTRADERMAL ADMINISTRATION OF RECOMBINANT HUMAN IL-36γ

A. A. Kolobov; Колобов А. А.; T. A. Sazonova; Сазонова Т. А.; G. V. Alexandrov; Александров Г. В.; A. V. Petrov; Петров А. В.

doi:10.31857/S102872210006690-4

THE MODEL OF PSORIASIFORM DERMATITIS IN MICE INDUCED BY INTRADERMAL ADMINISTRATION OF RECOMBINANT HUMAN IL-36γ

Authors: Kolobov A.A.¹, Sazonova T.A.¹, Alexandrov G.V.¹, Petrov A.V.¹
Affiliations:
1. State Research Institute of Highly Pure Biopreparations
Issue: Vol 22, No 2-2 (2019)
Pages: 807-809
Section: ORIGINAL ARTICLES
URL: https://rusimmun.ru/jour/article/view/308
DOI: https://doi.org/10.31857/S102872210006690-4
ID: 308

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Abstract

We developed and characterized the model of psoriasiform dermatitis in mice induced by induced by intradermal administration of recombinant human IL-36γ. Induced skin lesions resemble human psoriasis in means of both macroscopic (PASI) and microscopic features (acanthosis, parakeratosis, dermal leucocyte infiltration). This model can be used for anti-psoriatic drugs efficiency research.