Email this article RECEPTOR FUNCTIONS OF SEMA4D IN THE CONTROL OF T-LYMPHOCYTE PROLIFERATION
- Authors: Kuklina E.M.1
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Affiliations:
- “Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences”
- Issue: Vol 22, No 2-2 (2019)
- Pages: 840-842
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/358
- DOI: https://doi.org/10.31857/S102872210006679-1
- ID: 358
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Abstract
Сlass IV semaphoring Sema4D is widely represented in the immune system, both in membrane and in soluble form, and controls immune processes, realizing its effects through specific receptors ‒ these are generally accepted ideas. This paper presents data indicating the presence of an alternative way of Sema4D involvingin immunoregulation: this way suggests the functioning of membrane semaphorin as a receptor, which conducts a signal into the cell it is expressed on. Possible signaling mechanisms from membrane Sema4D are discussed.
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About the authors
E. M. Kuklina
“Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences”
Author for correspondence.
Email: ibis_07@mail.ru
Doctor of Biology, Leading Researcher, Laboratory of Immunoregulation,
Perm
Russian FederationReferences
- Kumanogoh A., Watanabe C., Lee I., Wang X., Shi W., Araki H., Hirata H., Iwahori K., Uchida J., Yasui T., Matsumoto M., Yoshida K., Yakura H., Pan C., Parnes J. R., Kikutani H. Identifi cation of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity. 2000, 13(5), 621–631.
- Kumanogoh A., Shikina T., Watanabe C., Takegahara N., Suzuki K., Yamamoto M., Takamatsu H., Prasad D. V., Mizui M., Toyofuku T., Tamura M., Watanabe D., Parnes J. R., Kikutani H. Requirement for CD100-CD72 interactions in fi ne-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment. Int Immunol. 2005, 17(10), 1277–1282.
- Herold C., Elhabazi A., Bismuth G., Bensussan A., Boumsell L. CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion. J Immunol. 1996, 157(12), 5262–5268.
- Witherden D. A., Watanabe M., Garij o O., Rieder S. E., Sarkisyan G., Cronin S. J., Verdino P., Wilson I. A., Kumanogoh A., Kikutani H., Teyton L., Fischer W. H., Havran W. L. The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. Immunity. 2012, 37(2), 314–325.
- Elhabazi A., Delaire S., Bensussan A., Boumsell L., Bismuth G. Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis. J Immunol. 2001, 166(7), 4341–4347.
- Billard C., Delaire S., Raffoux E., Bensussan A., Boumsell L. Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin atterminal B-cell differentiation stage. Blood. 2000, 95(3), 965–972.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).