EFFECTS OF BAY 11-7082 ON THE FORMATION OF IMMUNOSUPRESSOR DENDRITIC CELLS IN VITRO

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Abstract

Dendritic cells (DCs) regulate immune responses by modulating T and B cells in the direction of effector or tolerogenic responses. In this study, the effect of BAY 11-7082 on the formation of immunosuppressive DC of C57Bl/6 mice in vitro using recombinant IL-10 or TGF-β was evaluated. It was shown that the addition of BAY 11-7082 to the culture of immature DCs did not significantly affect the expression of the maturation molecules of dendritic cells (CD80, CD86). When using BAY 11-7082 in combination with IL-10 or TGF-β, reduced the expression of these molecules. The joint cultivation of DC with splenocytes in the presence of BAY 11-7082 and IL-10/TGF-β promoted the differentiation of regulatory T-cells (CD4+CD25hiFoxP3+) and did not contribute to the differentiation of CD4+ T-cells producing IL-10.

About the authors

V. V. Kurilin

Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”

Author for correspondence.
Email: 2221910@ngs.ru

PhD, Senior Researcher of the Laboratory of Molecular Immunology,

Novosibirsk

Russian Federation

Yu. N. Khantakova

Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”;
Novosibirsk State University

Email: fake@neicon.ru

PhD, Researcher of the Laboratory of Molecular Immunology;

Lecturer, Department of Fundamental Medicine, Institute of Medicine and Psychology V. Zelman,

Novosibirsk

Russian Federation

V. P. Tereshchenko

Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”

Email: fake@neicon.ru

Ph.D. student,

Novosibirsk

Russian Federation

E. V. Kulikova

Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”

Email: fake@neicon.ru

Ph.D., Researcher of the Laboratory of Molecular Immunology, 

Novosibirsk

Russian Federation

V. S. Melentiev

Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”

Email: fake@neicon.ru

Ph.D. student,

Novosibirsk

Russian Federation

I. A. Obleukhova

Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”

Email: fake@neicon.ru

Ph.D., Researcher, Laboratory of Molecular Immunology,

Novosibirsk

Russian Federation

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Copyright (c) 2019 Kurilin V.V., Khantakova Y.N., Tereshchenko V.P., Kulikova E.V., Melentiev V.S., Obleukhova I.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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