METABOLIC REPROGRAMMING OF MACROPHAGES ACTIVATED BY A NOD1 RECEPTOR AGONIST

Cover Page


Cite item

Full Text

Abstract

We provide the fi rst characterization of glucose and energy metabolism rearrangements in human macrophages upon their activation with a NOD1 receptor agonist (N-acetyl-D-muramyl-L-alanylD-isoglutamyl-meso-diaminopimelic acid, or M-triDAP) in comparison with the eff ects of a TLR4 agonist, lipopolysaccharide (LPS). We demonstrate possibilities of modulation of cytokine production by macrophages using glycolysis inhibitors.

About the authors

M. V. Pashenkov

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Author for correspondence.
Email: mvpashenkov@yandex.ru

Doctor of medical sciences, Acting head of the Laboratory of Clinical Immunology,

Moscow

Russian Federation

N. E. Murugina

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

junior researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

A. S. Budikhina

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

PhD, researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

P. V. Maximchik

Lomonosov Moscow State University

Email: fake@neicon.ru

PhD, researcher, Faculty of Fundamental Medicine, 

 

Russian Federation

Y. A. Dagil

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

L. S. Balyasova

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

junior researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

V. V. Murugin

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

PhD, researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

G. Z. Chkadua

FSBI “N. N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation

Email: fake@neicon.ru

PhD, senior researcher, Laboratory of experimental diagnostics and biotherapy of tumors,

Moscow

Russian Federation

B. V. Pinegin

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

Professor, Doctor of medical sciences, Head of the Department of immunodiagnostics and immunocorrection,

Moscow

Russian Federation

References

  1. O’Neill L. A., Pearce E. J. Immunometabolism governs dendritic cell and ma.crophage function. J Exp Med 2015, 213, 15–23.
  2. Jha A. K., Huang S. C., Sergushichev A., Lampropoulou V., Ivanova Y., Loginicheva E., Chmielewski K., Stewart K. M., Ashall J., Everts B., Pearce E. J., Driggers E. M., Artyomov M. N. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity 2015, 42 (3), 419–430.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2019 Pashenkov M.V., Murugina N.E., Budikhina A.S., Maximchik P.V., Dagil Y.A., Balyasova L.S., Murugin V.V., Chkadua G.Z., Pinegin B.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies