ANTIPATERNAL ANTI-LEUKOCYTE ANTIBODIES AS MARKERS OF THE EFFICACY OF ALLOIMMUNIZATIONIN WOMEN WITH RECURRENT PREGNANCY LOSS

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Abstract

The indicator of efficacy of lymphocyte immunotherapy (LIT) in women with recurrent pregnancy loss(RPL) is the level of antipaternal anti-leukocyte antibodies (APAB) detected by method of flow cytometry. The article presents the results of determining APAB in the dynamics of pregravid preparation and pregnancy in women with RPL and pregnancy outcomes after LIT.

About the authors

V. V. Vtorushina

Federal State Budget Institution «National medical research center of obstetrics, gynecology and Perinatology» of the Ministry of health of Russia

Author for correspondence.
Email: vtorushina@inbox.ru

Ph.D. in medical sciences, allergist-immunologist, doctor of laboratory diagnostics in Laboratory of Clinical Immunology,

Moscow

Russian Federation

L. V. Krechetova

Federal State Budget Institution «National medical research center of obstetrics, gynecology and Perinatology» of the Ministry of health of Russia

Email: fake@neicon.ru

Ph.D. in medical sciences, Head of Laboratory of Clinical Immunology,

Moscow

Russian Federation

N. K. Tetruashvili

Federal State Budget Institution «National medical research center of obstetrics, gynecology and Perinatology» of the Ministry of health of Russia

Email: fake@neicon.ru

Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy,

Moscow

Russian Federation

M. A. Nikolaeva

Federal State Budget Institution «National medical research center of obstetrics, gynecology and Perinatology» of the Ministry of health of Russia

Email: fake@neicon.ru

Doctor of Science, Leading researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

References

  1. Кречетова Л. В., Тетруашвили Н. К., Вторушина В. В., Николаева М. А., Голубева Е. Л., Сарибегова В. А., Агаджанова А. А., Ванько Л. В. Динамика выработки антилейкоцитарных антител в течение беременности у женщин с привычным выкидышем на фоне иммуноцитотерапии. Акушерство и гинекология. 2017, 9, 49–55.
  2. Кречетова Л. В., Николаева М. А., Ванько Л. В., Зиганшина М. М., Голубева Е. Л., Степанова Е. О., Сухих Г. Т. Оптимизация выявления антиотцовских антилейкоцитарных антител в сыворотке крови женщин с привычным невынашиванием после введения аллогенных лимфоцитов. Бюллетень экспериментальной биологии и медицины. 2012, Т. 153, 5, 684–688.

Copyright (c) 2019 Vtorushina V.V., Krechetova L.V., Tetruashvili N.K., Nikolaeva M.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


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