CONTENT OF GALECTINS-2, -9 AND SUBPOPULATIONS OF BLOOD MONOCYTES IN PATHOLOGY OF LUNG INFECTIOUS AND NON-INFECTIOUS GENESIS

Cover Page


Cite item

Full Text

Abstract

15 patients with infiltrative pulmonary tuberculosis (TB), 16 patients with chronic obstructive pulmonary disease (COPD) and 12 healthy donors were examined. Amount of CD14hiCD16–, CD14hiCD16lo, CD14loCD16lo and CD14loCD16– monocytes in the blood was evaluated by flow-cytometry, and galectin-2 and -9 concentration was measured by ELISA. Increase in the number of CD14hiCD16lo monocytes, differentiated from the CD14hiCD16– cells, and decrease in the content of galectin-2 and CD14lo CD16– monocytes in the blood were characteristic of TB. In COPD, an increase in the concentration of galectin-9 and the proportion of CD14hiCD16– monocytes against the background of deficiency of other their subpopulations in the blood was noted. 

About the authors

S. P. Chumakovа

Siberian State Medical University

Author for correspondence.
Email: fake@neicon.ru

Doctor of Medical Sciences, Professor at the Department of Pathophysiology,

Tomsk

Russian Federation

M. V. Vins

Siberian State Medical University

Email: wmw_1991@mail.ru

Assistant at the Department of Pathophysiology,

Tomsk

Russian Federation

O. I. Urazovа

Siberian State Medical University

Email: fake@neicon.ru

Doctor of Medical Sciences, Professor, Corresponding Member of the RAS, Head of the Department of Pathophysiology,

Tomsk

Russian Federation

E. B. Bukreeva

Siberian State Medical University

Email: fake@neicon.ru

Doctor of Medical Sciences, Professor of the Department of Internal Medicine Propaedeutics with the course of therapy of the Pediatric faculty,

Tomsk

Russian Federation

A. A. Bulanova

Siberian State Medical University

Email: fake@neicon.ru

PhD of Medical Sciences, Assistant of the Department of Internal Medicine Propaedeutics with the course of therapy of the Pediatric Faculty,

Tomsk

Russian Federation

E. G. Churinа

Siberian State Medical University

Email: fake@neicon.ru

Doctor of Medical Sciences, Professor at the Department of Pathophysiology,

Tomsk

Russian Federation

A. V. Sitnikovа

Siberian State Medical University

Email: fake@neicon.ru

Postgraduate at the Department of Pathophysiology,

Tomsk

Russian Federation

V. V. Novitsky

Siberian State Medical University

Email: fake@neicon.ru

Doctor of Medical Sciences, Professor, Academician of the RAS, Honored Scientist of the Russian Federation, Professor of the Department of Pathophysiology,

Tomsk

Russian Federation

References

  1. Yildirim C., Vogel D. Y., Hollander M. R., Baggen J. M., Fontij n R. D., Nieuwenhuis S., Haverkamp A., de Vries M. R., Quax P. H., Garcia-Vallejo J. J., van der Laan A. M., Dij kstra C. D., van der PouwKraan T.C., van Royen N., Horrevoets A. J. Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages. PLoS One, 2015, 10, 4, e0124347.
  2. Enninga E. A., Nevala W. K., Holtan S. G., Leontovich A. A., Markovic S. N. Galectin-9 modulates immunity by promoting Th2/M2 differentiation and impacts survival in patients with metastatic melanoma. Melanoma Res., 2016, 26, 5, 429–441.
  3. Barisionea C., Garibaldia S., Ghigliottia G., Fabbia P., Altieria P., Casalea M., Spallarossaa P., Berteroa G., Balbia M., Corsigliab L., Brunellia C. CD14CD16 monocyte subset levels in heart failure patients. Dis. Markers, 2010, 115–124.
  4. Ханин А. Л., Кравец С. Л. Хроническая обструктивная болезнь легких и туберкулез: актуальная проблема в реальной практике (обзор литературы). Вестник современной клинической медицины, 2017, 6, 60–70.
  5. Chihara М., Kurita М., Yoshihara Y., Asahina A., and Yanaba K. Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis. J Immunol Res. 2018, 9473243.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Chumakovа S.P., Vins M.V., Urazovа O.I., Bukreeva E.B., Bulanova A.A., Churinа E.G., Sitnikovа A.V., Novitsky V.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies