THE ROLE OF THE ENDOGENOUS OPIOID SYSTEM IN THE REGULATION OF ANTIBODY GENESIS DURING CHRONIC COLD STRESS

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Abstract

It was established that under conditions of chronic cold stress in mice, a decrease in the absolute and relative amount of antibody-forming cells in the spleen was observed. The blockade of opiate receptors led to the abolition of oppression.

About the authors

I. L. Sharav’eva

Institute of Ecology and Genetics of Microorganisms, UB RAS

Author for correspondence.
Email: irin.sh@gmail.com

PhD, recercher of the laboratory of biochemistry of development of microorganisms,

Perm

Russian Federation

S. V. Gein

Institute of Ecology and Genetics of Microorganisms, UB RAS;
Perm State University

Email: fake@neicon.ru

doctor of medicine deputy director for research;

professor Department of microbiology and immunology,

Perm 

Russian Federation

References

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  2. Toubia T., Khalife T. The Endogenous opioid system: role and dysfunction caused by opioid therapy. Clin Obstet Gynecol., 2019, 62, 3–10.
  3. Kido K., Shindo Y., Toda S., Masaki E. Expression of β-endorphin in peripheral tissues after systemic administration of lipopolysaccharide as a model of endotoxic shock in mice. Ann Endocrinol, 2018, 18, 30095–7.
  4. Гейн С. В., Шаравьева И. Л. Влияние блокады опиатных рецепторов на антителогенез и пролиферативный ответ спленоцитов при стрессе. Экспериментальная и клиническая фармакология, 2013, 1, 30–34.
  5. Jerne N. K., Nordin A. A. Plaque formation in agar by single antibody-producing cells. Science, 1963, 140, 405.

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Copyright (c) 2019 Sharav’eva I.L., Gein S.V.

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