THE INFLUENCE OF A NUMBER OF SUBSTITUTED 1,3,4-6H-THIADIAZINES ON THE CONTENT OF CYTOKINES IN BLOOD PLASMA OF RATS WITH EXPERIMENTAL DIABETES MELLITUS TYPE2

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Abstract

A study was carried out to investigate the impact of the L-17, a representative of 1,3,4-6H-thiadiazines, on the cytokine spectrum of rat blood plasma when simulating type 2 diabetes mellitus. Doses of nicotinamide and streptozotocin were respectively, 110 mg / kg and 65 mg / kg. The introduction of L-17 to diabetic rats was accompanied by a decrease in hyperglycemia and a partial correction of the imbalance in the content of pro-inflammatory and anti-inflammatory cytokines: a decrease in the level of IL-1α and IFN-γ without normalization of the IL-10 and TGF-β1 level.

About the authors

I. F. Gette

Ural Federal University named after the first president of Russia B. N. Yeltsin;
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Author for correspondence.
Email: i.goette@yandex.ru

Senior Researcher, Department of Immunochemistry, Institute of Chemical Technology;

PhD, Senior Researcher, Institute of Immunology and Physiology, 

620049, Sverdlovsk Region, Yekaterinburg, st. Pervomaiskaya 106

Russian Federation

V. V. Emelianov

Ural Federal University named after the first president of Russia B. N. Yeltsin

Email: fake@neicon.ru

PhD, Associate Professor, Department of Immunochemistry, Associate Professor, Department of Medical Biochemistry and Biophysics,

 

Russian Federation

A. V. Belousova

Ural Federal University named after the first president of Russia B. N. Yeltsin;
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

Laboratory Researcher, Department of Immunochemistry;

Junior Researcher, Institute of Immunology and Physiology, 

Ekaterinburg

Russian Federation

I. G. Danilova

Ural Federal University named after the first president of Russia B. N. Yeltsin;
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

Head of the Department of Medical Biochemistry and Biophysics;

Doctor of Biological Sciences, Associate Professor, Head of Laboratory of Morphology and Biochemistry,

Ekaterinburg

Russian Federation

L. P. Sidorova

Ural Federal University named after the first president of Russia B. N. Yeltsin

Email: fake@neicon.ru

Ph.D., Department of Life Safety, 

Ekaterinburg

Russian Federation

T. A. Tseitler

Ural Federal University named after the first president of Russia B. N. Yeltsin

Email: fake@neicon.ru

Ph.D., Associate Professor of the Department of Organic and Biomolecular Chemistry, 

Ekaterinburg

Russian Federation

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Copyright (c) 2019 Gette I.F., Emelianov V.V., Belousova A.V., Danilova I.G., Sidorova L.P., Tseitler T.A.

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