Email this article INFLUENCE OF CERULOPLASMIN ON CYTOKINE PRODUCTION DURING CHRONIC PHYSICAL LOADS OF SUBMAXIMAL POWER
- Authors: Ermolaeva E.N.1, Sashenkov S.L.1, Kantyukov S.A.1, Petuhova V.I.1, Jakovleva V.P.2
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Affiliations:
- FSBEI of Higher Education “South Ural State Medical University” of the Ministry of Health of the Russian Federation
- FSBEI of Higher Education “Ural State University of Physical Culture“
- Issue: Vol 22, No 3 (2019)
- Pages: 1140-1144
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/491
- DOI: https://doi.org/10.31857/S102872210007243-2
- ID: 491
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Abstract
Exercise was modeled in an experiment on 42 white mongrel rats. Chronic physical exercise submaximal power was modeled by daily swimming for 30 minutes – 21 days: the fi rst seven days the animals swam without load for 30 minutes, the next two weeks with a load of 2% of body weight. On the 9th, 15th and 21st day of the experiment, the animals were additionally subjected to maximum exercise: they swam for 4 minutes with a weight of 20% of their body weight. Ceruloplasmin was administered on the 1st, 4th and 7th day of physical activity, in a total dose of 60 mg / kg body weight. Blood sampling was carried out on the 9th, 15th and 21st day of the experiment. Under the experimental conditions in rats, it was shown that chronic physical exertion of submaximal power leads to the activation of the functional activity of leukocytes and an increase in the production of IL-6 by 15, 21 days and IL-4 by 21 days of the experiment. The introduction of ceruloplasmin during physical exertion of submaximal power levels out elevated levels of cytokines (IL-6, IL-4) and leads them to control indicators.
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About the authors
E. N. Ermolaeva
FSBEI of Higher Education “South Ural State Medical University” of the Ministryof Health of the Russian Federation
Author for correspondence.
Email: ermen33@mail.ru
PhD, associate professor, Department of Normal Physiology named after academician Yu. M. Zakharova,
Chelyabinsk
Russian FederationS. L. Sashenkov
FSBEI of Higher Education “South Ural State Medical University” of the Ministryof Health of the Russian Federation
Email: fake@neicon.ru
MD, professor, head of the Department of Normal Physiology named after academician Yu. M. Zakharova,
Chelyabinsk
Russian FederationS. A. Kantyukov
FSBEI of Higher Education “South Ural State Medical University” of the Ministryof Health of the Russian Federation
Email: fake@neicon.ru
PhD, associate professor, Department of biological chemistry named after R. Lifshits,
Chelyabinsk
Russian FederationV. I. Petuhova
FSBEI of Higher Education “South Ural State Medical University” of the Ministryof Health of the Russian Federation
Email: fake@neicon.ru
PhD, senior lecturer, Department of Normal Physiology named after academician Yu. M. Zakharova,
Chelyabinsk
Russian FederationV. P. Jakovleva
FSBEI of Higher Education “Ural State University of Physical Culture“
Email: fake@neicon.ru
PhD, associate professor, Department of Theory and Methods of Healthy Technologies and Physical Culture of the East,
Chelyabinsk
Russian FederationReferences
- Tossige-Gomes R., Ottone V. O., Oliveira P. N. et al. Leukocytosis, muscle damage and increased lymphocyte proliferative response after an adventure sprint race. Braz J Med Biol Res, 2014, 47(6), 492–498.
- Tidball J. G. Mechanisms of muscle injury, repair, and regeneration. Compr Physiol, 2011, 1(4), 2029–2062.
- Ермолаева Е. Н., Кривохижина Л. В., Мезенцева Е. А. Изменение лейкоцитарных индексов при хронической физической нагрузке. Российский иммунологический журнал, 2015, 9(18), 2(1), 60–62.
- Kakanis M. W., Peake J., Brenu E. W. et al. The open window of susceptibility to infection after acute exercise in healthy young male elite athletes. Exerc Immunol Rev, 2010, 16, 119–137.
- Dias R., Frollini A. B., Brunelli D. T. et al. Immune parameters, symptoms of upper respiratory tract infections, and training-load indicators in volleyball athletes. Int J Gen Med, 2011, 4, 837–844.
- Hojman P., Brolin C., Nørgaard-Christensen N. et al. IL-6 released from muscles during exercise is stimulated by lactate-dependent protease activity. Am J Physiol Endocrinol Metab, 2019, 316(5), 940–947.
- Xu Y., Zhang Y., Ye J. IL-6: a potential role in cardiac metabolic homeostasis. Int J Mol Sci, 2018, 19(9), 2474.
- Gudiksen A., Schwartz C. L., Bertholdt L. et al. Lack of skeletal muscle IL-6 affects pyruvate dehydrogenase activity at rest and during prolonged exercise. PLoS One, 2016, 11(6), 0156460.
- Serrano A. L., Baeza-Raja B., Perdiguero E. et al. Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. Cell Metabolism, 2008, 7(1), 33–44.
- Prokopchuk O., Liu Y., Wang L. et al. Skeletal muscle IL-4, IL-4Ralpha, IL-13 and IL-13Ralpha1 expression and response to strength training. Exerc Immunol Rev, 2007, 13, 67–75.
- Rosa Neto J. C., Lira F. S., Oyama L. M. et al. Exhaustive exercise causes an anti-infl ammatory effect in skeletal muscle and a pro-inflammatory effect in dipose tissue in rats. Eur J Appl Physiol, 2009, 106(5), 697–704.
- Hoier B., Nordsborg N., Andersen S. et al. Pro- and anti-angiogenic factors in human skeletal muscle in response to acute exercise and training. J Physiol, 2012, 590(3), 595–606.
- Мжельская Т. И. Биологические функции церулоплазмина и их дефицит при мутациях генов, регулирующих обмен меди и железа (обзор). Бюллютень экспериментальной биологии и медицины, 2000, 130(8), 124–133.
- Halliwell В., Gutteridge J. M.C. Caeruloplasmin and the superoxide radical. Lancet, 1982, 2, 556–559.
- Sergeev A. G., Pavlov A. R., Revina A. A. et al. The mechanism of interaction of ceruloplasmin with superoxide radicals. Int J Biochem, 1993, 25(11), 1549–1554.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).