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ГОМЕОСТАТИЧЕСКАЯ ПРОЛИФЕРАЦИЯ: ОТ НОРМЫ К ПАТОЛОГИИ

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Аннотация

Гомеостатическая пролиферация это физиологический процесс, направленный на восполнение периферического пула T-лимфоцитов после лимфопении. Однако в некоторых условиях он может приобретать патологические черты и увеличивать риск развития аутоиммунных заболеваний. В данном обзоре мы постарались представить современный взгляд на механизмы гомеостаза эффекторных и регуляторных клеток, а также подробно рассмотрели негативные эффекты гомеостатической пролиферации, которые возникают в определенных условиях, и могут приводить к аутоиммунной патологии.

Об авторах

Д. В. Шевырев
ФГБНУ Научно-исследовательский институт фундаментальной и клинической иммунологии
Россия

аспирант лаборатории клинической иммунопатологии

630099, г. Новосибирск, ул. Ядринцевская, д.14



В. П. Терещенко
ФГБНУ Научно-исследовательский институт фундаментальной и клинической иммунологии
Россия

аспирант лаборатории молекулярной иммунологии

Новосибирск



В. А. Козлов
ФГБНУ Научно-исследовательский институт фундаментальной и клинической иммунологии
Россия

д. м. н., профессор, академик РАН, заведующий лабораторией клинической иммунопатологии

Новосибирск



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Для цитирования:


Шевырев Д.В., Терещенко В.П., Козлов В.А. ГОМЕОСТАТИЧЕСКАЯ ПРОЛИФЕРАЦИЯ: ОТ НОРМЫ К ПАТОЛОГИИ. Российский иммунологический журнал. 2018;21(2):91-105.

For citation:


Shevyrev D.V., Tereshchenko V.P., Kozlov V.A. HOMEOSTATIC PROLIFERATION: FROM HEALTH TO PATHOLOGY. Russian Journal of Immunology. 2018;21(2):91-105. (In Russ.)

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