INFLUENCE OF GLUTAMIL-TRIPTOFAN ON THE EXPRESSION OF IL-8 AND ICAM-1 MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY 926 LINE

T. A. Kudryavtseva; Кудрявцева Т. А.; E. A. Starikova; Старикова Э. А.; N. A. Aktureeva; Актуреева Н. А.; S. V. Petlenko; Петленко С. В.; V. S. Smirnov; Смирнов В. С.; N. I. Stukan; Стукань Н. И.; A. V. Lyovina; Лёвина А. В.

INFLUENCE OF GLUTAMIL-TRIPTOFAN ON THE EXPRESSION OF IL-8 AND ICAM-1 MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY 926 LINE

Authors: Kudryavtseva T.A.¹, Starikova E.A.², Aktureeva N.A.², Petlenko S.V.¹, Smirnov V.S.¹, Stukan N.I.¹, Lyovina A.V.¹
Affiliations:
1. ZAO "MBNPK "Cytomed"
2. Institute of Experimental Medicine
Issue: Vol 20, No 2 (2017)
Pages: 157-158
Section: Articles
URL: https://rusimmun.ru/jour/article/view/611
ID: 611

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Abstract

The aim of the study was to investigate the cell mechanisms mediating immunomodulatory effects of a-glutamyl-tryptophan (EW) and estimate the possibility of this pharmaceutical agent to impact the level of NF-kp phosphorylation. Using in vitro model of inflammation, we tested whether EW impacts spontaneous and TNFa induced IL-8 secretion as well as ICAM-1 expression by endothelial EA.hy 926 cells and mononuclear leukocytes of human peripheral blood. Revealed inhibition of pro-inflammatory cytokine production can contribute to anti-inflammatory effects of EW. However a capability of EW to increase ICAM-1 expression suggests its cell activating function. Thus, due to diverse effects it seems unlikely that EW influences NF-kp directly.

Keywords

глутамил-триптофан, эндотелиальные клетки EA.hy 926, мононуклеар-ные лейкоциты периферической крови человека, ICAM-1, секреция цитокинов, glutamil-tryptophane, endotelialny cages of EA.hy 926, mononuclear leukocytes of peripheral blood of the person, ICAM-1, secretion of cytokin

References

Смирнов В. С. Современные средства профилактики и лечения гриппа и ОРВИ. СПб: ФАР-МИндекс. - 2010. - ISBN 978-5-91753-015-4.
Smirnov V. S. Modern drugs of prevention and treatment of influenza and acute respiratory viral infections. SPb: PHARMIndex.- 2010.- ISBN 978-5-91753-015-4.
Rahman A., Fazal F. Antioxid Redox Signal.- 2009.-V.11.- № 4.- Р.823-39.
Springer T. A., Dustin M. L. Curr Opin Cell Biol.-2012.- V.24.- № 1.- Р.107-15.

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INFLUENCE OF GLUTAMIL-TRIPTOFAN ON THE EXPRESSION OF IL-8 AND ICAM-1 MONONUCLEAR LEUKOCYTES OF PERIPHERAL BLOOD OF THE PERSON AND CAGES OF THE EA.HY 926 LINE

Full Text

Abstract

Keywords

About the authors

T. A. Kudryavtseva

E. A. Starikova

N. A. Aktureeva

S. V. Petlenko

V. S. Smirnov

N. I. Stukan

A. V. Lyovina

References

Supplementary files

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