TREATMENT-AND-PROPHYLACTIC EFFICIENCY OF SYNTHETIC PEPTIDE OF GLUTAMIL-TRYPTOPHANE AT THE VISCERAL PATHOLOGY CAUSED BY A HEAVY MECHANICAL POLYTRAUMA

S. V. Petlenko; Петленко С. В.; V. S. Smirnov; Смирнов В. С.; N. I. Stukan; Стукань Н. И.; A. V. Lyovina; Лёвина А. В.; A. N. Zhekalov; Жекалов А. Н.; E. A. Malakhova; Малахова Е. А.; M. E. Meshkova; Мешкова М. Е.

TREATMENT-AND-PROPHYLACTIC EFFICIENCY OF SYNTHETIC PEPTIDE OF GLUTAMIL-TRYPTOPHANE AT THE VISCERAL PATHOLOGY CAUSED BY A HEAVY MECHANICAL POLYTRAUMA

Authors: Petlenko S.V.¹, Smirnov V.S.¹, Stukan N.I.¹, Lyovina A.V.¹, Zhekalov A.N.², Malakhova E.A.², Meshkova M.E.²
Affiliations:
1. ZAO "MBNPK "Cytomed"
2. FGBVOOU VO "Army medical college of S. M. Kirov"
Issue: Vol 20, No 2 (2017)
Pages: 199-201
Section: Articles
Submitted: 22.10.2020
Published: 15.04.2017
URL: https://rusimmun.ru/jour/article/view/625
ID: 625

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Abstract

The efficacy and safety of using synthetic dipeptide alpha-glutamyl-tryptophan in the complex therapy of severe mechanical polytrauma of various nature were investigated. The trial included 327 people. Patients were randomly assigned to two groups: experimental and control (160 and 167 people, respectively). Both groups received standard combination therapy, but the experimental group received additionally the immunotropic drug "Timogen^®" (alpha-glutamyl-tryptophan). The drug was administered intramuscularly in a daily dose of 100 mcg during 10-day course not later than 24 hours after traumatic injuries. The structure, the severity and the progress of the visceral pathology, as well as dynamics of the immune system were evaluated in the comparative groups. "Timogen^®" facilitates reduction of the incidence of visceral complications, and if they develop, it decreases duration of the main clinical manifestations normalizing the structural, quantitative and functional parameters of the immune system and accelerating regeneration of damaged tissues in patients with severe mechanical polytrauma.

Keywords

глутамил-триптофан, висцеральная патология, политравма, glutamyl-tryptophan, polytrauma, visceral pathology

References

Комаревцев В.Н., Петленко С. В., Жекалов А. Н. с соавт// Разработка новых комплексных патогенетически обусловленных направлений ранней реабилитации раненных с травматической болезнью // Методические рекомендации по теме НИР № 2.00.336.п.4 «Кавказ-3»СПБ.- ВМедА.- 2000.- 25с.
Дамбинова С. А., Комаревцев В. Н., Алексеев А. Н. с соавт.// Применение поликомпонентного растительного препарата «Содекор» в схеме лечения травматической болезни// Актуальные вопросы военно-полевой терапии: материалы Всеармейской науч.- практ. конф. Медицинские последствия экстремальных воздействий на организм.- СПб.- 2000.- С. 222-223.

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TREATMENT-AND-PROPHYLACTIC EFFICIENCY OF SYNTHETIC PEPTIDE OF GLUTAMIL-TRYPTOPHANE AT THE VISCERAL PATHOLOGY CAUSED BY A HEAVY MECHANICAL POLYTRAUMA

Full Text

Abstract

Keywords

About the authors

S. V. Petlenko

V. S. Smirnov

N. I. Stukan

A. V. Lyovina

A. N. Zhekalov

E. A. Malakhova

M. E. Meshkova

References

Supplementary files

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