THE IMPACT OF THE AMINO ACID ARGININE ON THE COURSE OF EXPERIMENTAL TUBERCULOUS PROCESS IN ANIMALS WITH DIFFERENT SENSITIVITY TO TUBERCULOSIS

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Abstract

On the model of experimental tuberculosis of guinea pigs to study the effect of amino acid arginine on the course of the tuberculosis process. Experiments were carried out on 75 guinea pigs and 25 rats (weighing 200-250 g). To reproduce experimental tuberculosis, a museum strain of mycobacteria was used at the Central Research Institute of Tuberculosis H37Rv, 1993. Groups of animals: 3 groups of guinea pigs of 25 pcs. (Healthy control, infected with ILW and infected with ILT, receiving arginine daily 10 mg / kg body weight of the animal for a month) and 2 groups of rats of 25 pieces (healthy control, infected with ILW and infected with MBT). Determined in the blood nitrites and nitrates, total lipid peroxides by ELISA Biomedica GRUPPE and R & D Systems. Results. In animals lacking resistance to tuberculosis infection, increased plasma levels of nitric oxide derivatives caused by the use of arginine is an unfavorable factor contributing to the progression of tuberculosis.

About the authors

E. V. Sabadash

The FGBI "Ural research Institute of Phthisiopulmonology, Ministry of healthcare of the Russian Federation; FGBOU USMU

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

S. N. Skornyakov

The FGBI "Ural research Institute of Phthisiopulmonology, Ministry of healthcare of the Russian Federation; FGBOU USMU

Email: noemail@neicon.ru
Russian Federation

V. A. Pavlov

The FGBI "Ural research Institute of Phthisiopulmonology, Ministry of healthcare of the Russian Federation; FGBOU USMU

Email: noemail@neicon.ru
Russian Federation

B. I. Novikov

The FGBI "Ural research Institute of Phthisiopulmonology, Ministry of healthcare of the Russian Federation; FGBOU USMU

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2017 Sabadash E.V., Skornyakov S.N., Pavlov V.A., Novikov B.I.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


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