Email this article EFFECT OF THE AUTOLOGOUS APOPTOTIC CELL CULTURES ON THE PARAMETERS OF EARLY AND LATE APOPTOSIS OF T LYMPHOCYTES FROM HEALTHY DONORS
- Authors: Abramova T.Y.1, Tsura V.A.1, Blinova E.A.1, Kozlov V.A.1
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Affiliations:
- Federal state budgetary organization "Research Institute of Fundamental and Clinical Immunology"
- Issue: Vol 20, No 2 (2017)
- Pages: 236-238
- Section: Articles
- URL: https://rusimmun.ru/jour/article/view/636
- ID: 636
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Abstract
In healthy people, it has been established the possibility of induction of early and late apoptosis of T-lym-phocytes proliferated in vitro under physiological conditions through the transfer of both the cellular and humoral components of an autologous apoptotic T cell culture. It was determined that under equal conditions of cultivation of lymphocytes: a high cell density and a depletion of the culture medium, the transfer of components of the cells stimulated by anti-CD3 antibodies regularly increased the sensitivity of T-lymphocytes to apoptosis. While transfer of components of the culture with the dexamethasone exerted a modulating effect.
About the authors
T. Ya. Abramova
Federal state budgetary organization "Research Institute of Fundamental and Clinical Immunology"
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
V. A. Tsura
Federal state budgetary organization "Research Institute of Fundamental and Clinical Immunology"
Email: noemail@neicon.ru
Russian Federation
E. A. Blinova
Federal state budgetary organization "Research Institute of Fundamental and Clinical Immunology"
Email: noemail@neicon.ru
Russian Federation
V. A. Kozlov
Federal state budgetary organization "Research Institute of Fundamental and Clinical Immunology"
Email: noemail@neicon.ru
Russian Federation
References
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- Sadallah S. Ectosomes as modulators of inflammation and immunity / S. Sadallah, C. Eken, J. A. Schifferli // Clinical and Experimental Immunology.- 2010.- Vol. 163.- P. 26-32.
- Baschant, U. The role of the glucocorticoid receptor in inflammation and immunity / U. Baschant, J. Tuckermann // J Steroid Biochem Mol Biol.-2010.- Vol. 12.- P. 69-75.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).