Email this article ALLERGIC DISEASES AND HELICOBACTER PYLORI INFECTION PART 1. sIgE HUMORAL IMMUNE RESPONSE TO H. PYLORI
- Authors: Gervazieva V.B.1, Mazurina S.A.1, Ilintseva N.V.1
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Affiliations:
- I. Mechnikov Research Institute of Vaccines & Sera
- Issue: Vol 20, No 2 (2017)
- Pages: 275-277
- Section: Articles
- URL: https://rusimmun.ru/jour/article/view/653
- ID: 653
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Abstract
Serum samples, taken from 12-17 aged children with allergic and concomitant gastrointestinal diseases have been analyzed by ELISA for the total IgE, IL-4, IL-10, IgG, IgA and sIgE to H.pylori. IgE-response to H.pylori prevailed over IgA и IgG Abs and was enhanced in groups of children with allergic diseases and chronic gastroduodenitis, particularly during the exacerbation of allergy. Among children with erosive and ulcerous gastritis and also in group of non-allergic patients with chronic gastroduodenitis, the levels and frequency of sIgE to H.pylori were significantly lower than in healthy controls. The secretion of sIgE to H.pylori is supposed as one of the protective mechanisms under the conditions of chronic mucosal inflammation, associated with favorable outcomes of gastrointestinal diseases.
About the authors
V. B. Gervazieva
I. Mechnikov Research Institute of Vaccines & Sera
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
S. A. Mazurina
I. Mechnikov Research Institute of Vaccines & Sera
Email: noemail@neicon.ru
Russian Federation
N. V. Ilintseva
I. Mechnikov Research Institute of Vaccines & Sera
Email: noemail@neicon.ru
Russian Federation
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).