CONDITION OF THE IMMUNE SYSTEM ORGANS AND BLOOD LEUCOCYTES IN RATS AFTER THE EXPOSITION OF IRON-MOLYBDENUM POLYOXOMETALATES

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Abstract

When iron-molybdenum polyoxometalates (POM) were introduced to rats, the accumulation of heat shock proteins (HSP) in the thymus and spleen were revealed without altering the histological structure of the organs. This finding indicates both the stressing impact of the POM and the protective action of the HSP. Lymphocyte apoptosis increase and H1 histone protein increase are supposed to be indicators preceding the destructive changes in immunopoietic organs.

About the authors

I. F. Gette

Ural Federal University; Institute of Immunology and Physiology, Ural Branch of RAS

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

S. Yu. Medvedeva

Ural Federal University; Institute of Immunology and Physiology, Ural Branch of RAS

Email: noemail@neicon.ru
Russian Federation

A. A. Ostroushko

Ural Federal University

Email: noemail@neicon.ru
Russian Federation

References

  1. Zager R.A. Progressive histone alterations and proin-flammatory gene activation: consequences of heme protein/iron-mediated proximal tubule injury/ Zager R.A., Johnson A.C. // Am J Physiol Renal Physiol.-2010.- № 298(3).- P. 827-37.
  2. Гетте И. Ф. Содержание гистоновых белков в лимфоцитах крови и проявление воспалительного процесса/ Гетте И. Ф., Данилова И. Г., Остроушко А. А. // Российский иммунологический журнал.- 2015.- № 2(1). 9(18).- С. 444-445.
  3. Guidelines for the nomenclature of the human heat shock proteins / Kampinga HH, Hageman J, Vos MJ et al. // Cell Stress Chaperones - 2009.- 14 (1).- P. 105-11.
  4. Archimedian Synthesis and Magic Numbers: "Sizing" Giant Molybdenum - Oxide Based Molecular Spheres of the Keplerate Type./ Muller A., Sarkar S., Nazir Shah S. Q. et al. // Angew. Chem. Int. Ed. Engl.- 1999.- V. 38.- P. 3238-41.
  5. Ядерные белки хроматина в оценке эффективности лечения больных псориазом / Маркушева Л. И., Савина М. И., Решина В. М. // Клиническая лабораторная диагностика.- 2000.- № 7.- С. 18-20.

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Copyright (c) 2017 Gette I.F., Medvedeva S.Y., Ostroushko A.A.

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