CYTOKINES' RESPONSE UNDER SEPSIS AND TRAUMA

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  • Authors: Zotova N.V.1,2, Gusev E.Y.1,2, Zubova T.E.1
  • Affiliations:
    1. Institute of Immunology and Physiology of UB RAS
    2. Auto Federal State Autonomous Educational Institution of Higher Professional Education "Ural Federal University named after the first President of Russia B. N. Yeltsin"
  • Issue: Vol 20, No 2 (2017)
  • Pages: 336-337
  • Section: Articles
  • Submitted: 22.10.2020
  • Published: 15.04.2017
  • URL: https://rusimmun.ru/jour/article/view/677
  • ID: 677

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Abstract

We detected rates of IL-6, -8, -10, TNF-α, and CRP in plasma of patients with sepsis and polytrauma at 1-2nd and 5-7th days after admission in ICU. All patients were divided into groups with/ without MODS development. A rise in mediator levels in all groups of patients were identified. The maximum of detected increasing was in patients with MODS. There was not a clear cytokines-etiological agent dependence.

About the authors

N. V. Zotova

Institute of Immunology and Physiology of UB RAS; Auto Federal State Autonomous Educational Institution of Higher Professional Education "Ural Federal University named after the first President of Russia B. N. Yeltsin"

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

E. Yu. Gusev

Institute of Immunology and Physiology of UB RAS; Auto Federal State Autonomous Educational Institution of Higher Professional Education "Ural Federal University named after the first President of Russia B. N. Yeltsin"

Email: noemail@neicon.ru
Russian Federation

T. E. Zubova

Institute of Immunology and Physiology of UB RAS

Email: noemail@neicon.ru
Russian Federation

References

  1. Binkowska A. M., Michalak G., Slotwihski R. Current views on the mechanisms of immune responses to trauma and infection. Cent. Eur. J. Immunol. 2015, 40(2), 206-216.
  2. Черешнев В. А., Гусев Е. Ю., Зотова Н. В. Фундаментально-прикладные аспекты системного воспаления с позиции теории физиологических и типовых патологических процессов. Рос. Физиол. Журн. им. И. М. Сеченова. 2010, 96 (7), 696-707.
  3. Singer M., Deutschman C. S., Seymour C. W., Shankar-Hari M., Annane D., et al. The Third International Consensus Defi nitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016, 315 (8), 801-810.

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Copyright (c) 2017 Zotova N.V., Gusev E.Y., Zubova T.E.

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