PREVALENCE OF ANTINUCLEAR ANTIBODY IN CHILDREN WITH REACTIVE ARTHRITIS

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Abstract

Children with reactive arthritis (n=26) of 2-17 years old were examinated. Antinuclear antibodies were determined by indirect immunofluorescence assay, antibodies to extractable nuclear antigens were defined by ELISA. It was found that 12 patients (46 %) with reactive arthritis had diagnostic titers of antinuclear antibodies detected by indirect immunofluorescence assay. Homogeneous and speckled fluorescence patterns were observed in patients with reactive arthritis. The prevalence of antibodies to extractable nuclear antigens in children with reactive arthritis was low (8 %).

About the authors

I. M. Krivolapova

Regional Child's Clinical Hospital № 1; Institute of Immunology and Physiology Ural Branch of the Russian Academy of Sciences

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

I. A. Pashnina

Regional Child's Clinical Hospital № 1; Institute of Immunology and Physiology Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

V. A. Chereshnev

Institute of Immunology and Physiology Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

References

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  2. Пашнина И. А., Криволапова И. М., Козло ва Е. С., Скоробогатова О. В., Тузанкина И. А., Черешнев В. А. Аутоантитела при ювенильных артритах у детей. Российский иммунологический журнал 2013, том 7(16), 4, 437-444.
  3. Алексеева Е. И., Чистякова Е. Г. Реактивный артрит. В кн.: Педиатрия: национальное руководство краткое издание. ГЭОТАР-Медиа, Москва 2014,177-196.
  4. Malleson P. N., Sailer M., Machinnon M. J. Useful-lness of antinuclear antibody testing to screen for rheumatic diseases. Archives of Disease in Childhood. 1997, 77, 299-304.
  5. Лапин С. В., Тотолян А. А. Иммунологическая лабораторная диагностика аутоиммунных заболеваний. Человек, Санкт-Петербург 2010, 272.

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Copyright (c) 2017 Krivolapova I.M., Pashnina I.A., Chereshnev V.A.

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