APOPTOSIS OF MONOCYTES, THEIR METABOLIC FUNCTIONS AND CYTOKINE PROFILE, WITH LIMITED AND SYSTEMIC SCLERODERMA

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Abstract

With systemic scleroderma demonstrated activation of apoptosis of monocytes, their metabolic functions against the background of increasing levels of proinflammatory cytokines. Limited scleroderma significant changes in rates of apoptosis of monocytes, their metabolic functions of the profile was not found on the background of the increasing of proinflammatory cytokines.

About the authors

N. V. Romanova

State Medical University

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

E. N. Erygina

State Medical University

Email: noemail@neicon.ru
Russian Federation

V. A. Romanov

State Medical University

Email: noemail@neicon.ru
Russian Federation

References

  1. Sato S. et al. Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis. Mol. Immunology. 2004. 41 (12). 1123-1133.
  2. Takehara K., Sato S. Localized scleroderma is an autoimmune disorder. Rheumatology (Oxford). 2005. 44 (3). 274-279.
  3. Gabrielli A. et al. New Insights into the Role of Oxidative Stress in Scleroderma Fibrosis. Open Rheumatol J. 2012. 6. 87-95.
  4. Shroff A. et al. Oxidative Stress and Skin Fibrosis. Curr Pathobiol Rep. 2014. 2(4).257-267.
  5. Хаитов P. M. и др. Экологическая иммунология. М: ВНИРО; 1995.

Copyright (c) 2017 Romanova N.V., Erygina E.N., Romanov V.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


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