INDUCTION OF ANTIGENIC DETERMINANTS FOR REGULATORY RHEUMATHOID FACTOR ON FC FRAGMENTS OF HUMAN IgG

A. Yu. Sidorov; Сидоров А. Ю.; E. Yu. Stolyarova; Столярова Е. Ю.; T. V. Khramova; Храмова Т. В.; A. S. Terentiev; Терентьев А. С.; M. P. Irina; Ирина М. П.; A. M. Gorbushina; Горбушина А. М.; L. A. Paderina; Падерина Л. А.

INDUCTION OF ANTIGENIC DETERMINANTS FOR REGULATORY RHEUMATHOID FACTOR ON FC FRAGMENTS OF HUMAN IgG

Authors: Sidorov A.Y.¹, Stolyarova E.Y.¹, Khramova T.V.¹, Terentiev A.S.¹, Irina M.P.¹, Gorbushina A.M.¹, Paderina L.A.¹
Affiliations:
1. Udmurt State University
Issue: Vol 20, No 3 (2017)
Pages: 501-503
Section: Articles
URL: https://rusimmun.ru/jour/article/view/743
ID: 743

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Abstract

Recently, we detected a rheumatoid factor, called regulatory, whose production prevents development and causes a remission of experimentally-induced autoimmune diseases. The aim of this study was to elucidate the mechanism of induction of antigenic determinants for regulatory rheumatoid factor onIgG and Fc fragments of human IgG. It was found out that antigenic determinants for regulatory rheumatoid factor are formed in the hinge region of IgG uponthe reduction of sulfhydryl bondby treatment of the IgG molecule with polyethylene glycol or dithiothreitol. In response to the immunization of rats with native human IgG, the production of antibodies similar in specificity to human regulatory rheumatoid factor occurs, suggests that there is an endogenous mechanism for the formation of neoantigenic determinants for regulatory rheumatoid factor

Keywords

антигенные детерминанты, регуляторный ревматоидный фактор, Fc фрагменты IgG, аутоиммунные заболевания, шарнирная область IgG, antigenic determinants, regulatory rheumatoid factor, Fc fragments IgG, autoimmune diseases, hinge region IgG

References

BedulevaL., MenshikovI., StolyarovaE., FominaK., LobanovaO., et al., Rheumatoid factor in idiotypic regulation of autoimmunity, Int. J. Rheum Dis. 2015, 18, 408-420.
Sidorov A., Beduleva L., Menshikov I., Terentiev A., Stolyarova E. et al. Fc fragments of immunoglobulin G are an inductor of regulatory rheumatoid factor and a promising therapeutic agent for rheumatic diseases. Int. J. Biol. Macromolec. 2017, 95, 938-945.

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INDUCTION OF ANTIGENIC DETERMINANTS FOR REGULATORY RHEUMATHOID FACTOR ON FC FRAGMENTS OF HUMAN IgG

Full Text

Abstract

Keywords

About the authors

A. Yu. Sidorov

E. Yu. Stolyarova

T. V. Khramova

A. S. Terentiev

M. P. Irina

A. M. Gorbushina

L. A. Paderina

References

Supplementary files

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