CYTOKINE PROFILE IN PATIENTS WITH ASEPTIC NECROSIS OF THE FEMORAL HEAD

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Abstract

The levels of serum cytokines were investigated in 17 patients with aseptic necrosis of the femoral head before surgery total joint replacement aged between 33 and 57. A significant increase in the blood compared to normal levels of TNF-α, IL-17, IL - 4, IL-10 as well as the decrease of IFN-γ was determined. The identified imbalance of cytokines which are positively and negatively regulating the osteoclastogenesis may contribute to an increased resorption of bone tissue in this pathology.

About the authors

A. V. Chekushkin

SEIHPE Orenburg State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

A. A. Safronov

SEIHPE Orenburg State Medical University, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

Al. A. Safronof

SEIHPE Orenburg State Medical University, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

Y. V. Filippova

SEIHPE Orenburg State Medical University, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

A. M. Matiyash

SEIHPE Orenburg State Medical University, Ministry of Health of Russia

Email: noemail@neicon.ru
Russian Federation

References

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  2. Ginaldi L., De Martinis M. Osteoimmunology and Beyond. Cur. Medicinal Chemistry 2016, Vol. 23, № 33, 3754-3774.
  3. Матвеичев А. В., Талаев В. Ю., Евплова И. А. Физиология и функционирование Т-хелперов 17-го типа. Успехи современной биологии 2016, Т. 136, № 3, 285-300.
  4. Чекушкин А. В., Сафронов А. А., Сафронов А. А. и др. Особенности иммунного статуса у пациентов с асептическим некрозом головки бедренной кости. Российский иммунологический журнал 2016, Т. 10 (19), № 2 (1), 248-250.

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Copyright (c) 2017 Chekushkin A.V., Safronov A.A., Safronof A.A., Filippova Y.V., Matiyash A.M.

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