THE ROLE OF CERTAIN BLOOD CYTOKINES AND FACTORS OF INNATE IMMUNITY FOR PREDICTION OF REACTIVE ARTHRITIS OUTCOME

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Abstract

The clinical and immunological examination of children with reactive arthritis (ReA) and discriminant analysis allowed to establish significant serum factors associated with the clinical variant of ReA (IL-17, IL-6, INF-γ, lysozyme, CRP), which indicates a possible Use them as markers for predicting the clinical course of ReA and the outcome of arthritis.

About the authors

O. E. Chelpachenko

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

E. I. Danilova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

I. A. Nikiforov

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

L. P. Fedotova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
Russian Federation

References

  1. Scher J. U. Microbiome in inflammatory arthritis and human rheumatic diseases / J. U. Scher, D. R. Littman, S. B. Abramson // Arthritis Rheumatol.- 2016.- Vol.68, N.1.- P. 35-45.
  2. Sieper J. Pathogenesis of reactive arthritis / J. Sieper // Curr Rheumatol Rep.- 2001.- N. 3.- P. 412-418.
  3. Rosenbaum J. T. The microbiome: A revolution in treatment for rheumatic diseases? / J. T. Rosenbaum, M. J. Asquith // Curr. Rheumatol. Rep.- 2016.- N. 18.- P. 62.
  4. Elevated levels of serum MRP8/14 in ankylosing spondylitis: Associated with peripheral arthritis and active disease / L. Gupta, S. Bhattacharya, V. Ag-garwal et al. // Clin. Rheumatol.- 2016.- Vol. 35, N.12.- P. 3075-3079.

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Copyright (c) 2017 Chelpachenko O.E., Danilova E.I., Nikiforov I.A., Fedotova L.P.

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