REGULATION OF NK CELLS FUNCTIONAL ACTIVITY BY REPRODUCTIVE HORMONES

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Abstract

The influence of reproductive hormones on phenotypic characteristics, cytokine production and the level of lytic activity of natural killer (NK) cells was studied. The role of miRNAs in the hormonal mechanisms of formation of regulatory and cytotoxic NK cells subpopulations during pregnancy was investigated. The new physiological mechanisms of endocrine control of mother’s immune system NK cells that can be implemented in different periods of pregnancy were identified as a result of this work.

About the authors

S. V. Shirshev

Institute of Ecology and Genetics of Microorganisms, Russian Academy of Science, Ural Branch

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

I. V. Nekrasova

Institute of Ecology and Genetics of Microorganisms, Russian Academy of Science, Ural Branch

Email: noemail@neicon.ru
Russian Federation

O. L. Gorbunova

Institute of Ecology and Genetics of Microorganisms, Russian Academy of Science, Ural Branch

Email: noemail@neicon.ru
Russian Federation

E. G. Orlova

Institute of Ecology and Genetics of Microorganisms, Russian Academy of Science, Ural Branch

Email: noemail@neicon.ru
Russian Federation

I. L. Maslennikova

Institute of Ecology and Genetics of Microorganisms, Russian Academy of Science, Ural Branch

Email: noemail@neicon.ru
Russian Federation

References

  1. Vacca P., Moretta L., Moretta A., Mingari M. C. Origin, phenotype and function of human natural killer cells in pregnancy. Trends Immunol. 2011, 32, 517-523.
  2. Koopman L. A., Kopcow H. D., Rybalov B. et al. Human decidual natural killer cells are a unique NK subset with immunomodulatory potential. J. Exp. Med. 2003, 198, 1201.
  3. Trotta R., Chen L., Ciarlariello D. et al. miR-155 regulates IFN-γ production in natural killer cells. Blood 2012, 119(15), 34783485.
  4. Elemam N. M., Mekky R. Y., El-Ekiaby N.M. et al. Repressing PU.1 by miR-29a in NK cells of HCV patients, diminishes its cytolytic effect on HCV infected cell models. Hum. Immunol. 2015, 76, 687-694.
  5. Wang P., Gu Y., Zhang Q. et al. Identification of resting and type I IFN-activated human NK cell miR-Nomes reveals microRNA-378 and microRNA-30e as negative regulators of NK cell cytotoxicity. J. Immunol. 2012, 189, 211-221.

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Copyright (c) 2017 Shirshev S.V., Nekrasova I.V., Gorbunova O.L., Orlova E.G., Maslennikova I.L.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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