Email this article Impact on ceruloplasmin on the chemiluminescence of neutrophils in chronic submaximal exercise capacity
- Authors: Ermolaeva E..1, Kantyukov S..1, Petuhova V..1, Surina-Marysheva E..2
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Affiliations:
- South Ural State Medical University
- South Ural State University (National Research University)
- Issue: Vol 21, No 3 (2018)
- Pages: 281-285
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/879
- DOI: https://doi.org/10.31857/S102872210002395-9
- ID: 879
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Abstract
Exercise simulated in an experiment on 59 white rats. Chronic physical load submaximal power modeled daily swimming for 30 minutes. The load was increased gradually: the fi rst seven days, the animals swam every day without a load, the next two weeks the animals swam with a load of 2% of body weight. On 9, 15 and 21 day of the experiment, the animals were subjected to an additional maximum exertion: swam for 4 minutes with a load weight of 20% of body weight. Blood sampling was carried out on 9, 15 and 21 days after the experiment exercise intracardiac. Ceruloplasmin was administered on the 1st, 4th and 7th day of physical activity, in a total dose of 60 mg / kg of body weight. The intensity of free radical oxidation in whole blood was investigated by luminol-enhanced chemiluminescence. Under experimental conditions in rats, it was shown that in the case of chronic physical exercise of submaximal power, the production of free radicals in neutrophils decreases. The introduction of ceruloplasmin does not lead to a reduction in the reduced production of free radicals by neutrophilic leukocytes during physical activity.
About the authors
E. . Ermolaeva
South Ural State Medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
S. . Kantyukov
South Ural State Medical University
Email: noemail@neicon.ru
Russian Federation
V. . Petuhova
South Ural State Medical University
Email: noemail@neicon.ru
Russian Federation
E. . Surina-Marysheva
South Ural State University (National Research University)
Email: noemail@neicon.ru
Russian Federation
References
- Panyushkin V. V., Rozhkov E. A., Tulova E. A. et al. Mechanisms of limiting physical performance hemodynamic disorders in microcirculation link. Bulletin of Sport Science, 2013, (2), 25–30.
- Pesic S., Jakovljevic V., Djordjevic D. et al. Exerciseinduced changes in redox status of elite karate athletes. Chin J Physiol, 2012, 55 (1), 8–15.
- Сурина-Марышева Е. Ф., Кривохижина Л. В, Кантюков С. А. и др. Влияние церулоплазмина на количество и резистентность эритроцитов при острой физической нагрузке. Бюл эксперим биол и мед, 2009, 148(8), 151–153.
- Фархутдинов Р. Р., Лиховских В. А. Хемилюминесцентные методы исследования свободнорадикального окисления в биологии и медицине, Уфа: Изд-во БГМИ, 1995, 90.
- Heinonen I., Kemppainen J., Kaskinoro K. et al. Eff ects of adenosine, exercise, and moderate acute hypoxia on energy substrate utilization of human skeletal muscle. Am J Physiol Regul Integr Comp Physiol, 2012, 302(3), 385–390.
- Little J. P., Safdar A., Wilkin G. P. et al. A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms. J Physiol, 2010, 588 (6), 1011–1022.
- Finaud J., Scislowski V., Lac G., Durand D. et al. Antioxidant status and oxidative stress in professional rugby players: evolution throughout a season. Int J Sports Med, 2006, 27(2), 87–93.
- Silva L. A., Silveira P. C. L., Ronsani M. M. et al. Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise. Cell biochemistry and function, 2011, 29(1), 43–49.
- Кантюков С. А., Ермолаева Е. Н., Кривохижина Л. В. Свободнорадикальное окисление в цельной крови при физических нагрузках различной длительности и интенсивности. Современные проблемы науки и образования, 2015, 6: URL: www.scienceedication. ru/130–23081.
- Мжельская Т. И. Биологические функции церулоплазмина и их дефицит при мутациях генов, регулирующих обмен меди и железа. Бюл эксперим биол и мед, 2000, 130 (8), 124–133.
- Ермолаева Е. Н., Кривохижина Л. В. Церулоплазмин в коррекции дислипидемии, вызванной хронической физической нагрузкой субмаксимальной мощности в эксперименте. Экспериментальная и клиническая фармакология, 2016, 79(6), 9–11.
- Ващенко В. И., Ващенко Т. Н. Церулоплазмин: от метаболита до лекарственного средства. Психофармакология и биологическая наркология, 2006, 6(3), 1254–1269.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).