Email this article CD57 expression by peripheral blood cytotoxic T cells in sarcoidosis
- Authors: Kudryavtsev I..1,2, Lazareva N..3, Baranova O..3, Serebriakova M..2, Ses’ T..3,4, Ilkovich M..3, Totolyan A..3,5
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Affiliations:
- Academician I. P. Pavlov First St. Petersburg State Medical University
- Institute of Experimental Medicine
- Academician I.P. Pavlov First St. Petersburg State Medical University
- State Research Institute of Highly Pure Biopreparations
- St. Petersburg Pasteur Institute,
- Issue: Vol 21, No 3 (2018)
- Pages: 329-334
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/889
- DOI: https://doi.org/10.31857/S102872210002405-0
- ID: 889
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Abstract
Using 10-color fl ow cytometry we characterized cytotoxic T cell subsets based on expression of CD45RA, CD62L, CD27, and CD28 and compared the expression of CD57 between these subsets in peripheral blood sample from patients with chronic sarcoidosis (n=46) and healthy volunteers (n=46). Circulating naive, central and eff ector memory as well as TEMRA CD3+CD8+ cells of sarcoidosis patients contained signifi cantly increased proportions CD57+ cells when compared with healthy controls. Interestingly, CD57 expression was increased in subsets with ‘non mature’ and intermediate phenotypes – EM1, EM2, EM4, pE1 and pE2. Our results indicate the involvement of CD3+CD8+ in maintenance in sarcoidosis as well as suggest CD57-positive cells to be the novel target for evaluation the eff ectiveness of sarcoidosis therapy.
About the authors
I. . Kudryavtsev
Academician I. P. Pavlov First St. Petersburg State Medical University; Institute of Experimental Medicine
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
N. . Lazareva
Academician I.P. Pavlov First St. Petersburg State Medical University
Email: noemail@neicon.ru
Russian Federation
O. . Baranova
Academician I.P. Pavlov First St. Petersburg State Medical University
Email: noemail@neicon.ru
Russian Federation
M. . Serebriakova
Institute of Experimental Medicine
Email: noemail@neicon.ru
Russian Federation
T. . Ses’
Academician I.P. Pavlov First St. Petersburg State Medical University; State Research Institute of Highly Pure Biopreparations
Email: noemail@neicon.ru
Russian Federation
M. . Ilkovich
Academician I.P. Pavlov First St. Petersburg State Medical University
Email: noemail@neicon.ru
Russian Federation
A. . Totolyan
Academician I.P. Pavlov First St. Petersburg State Medical University; St. Petersburg Pasteur Institute,
Email: noemail@neicon.ru
Russian Federation
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).