Examining dynamic changes in the complement system components and immune complexes of various fractions in adolescents with obesity and metabolic syndrome affected by antihypoxants

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Abstract

In this paper, we consider a relation between adolescent obesity and dynamic changes in the complement system components and immune complexes of various fractions affected by antihypoxants, because obesity is one of the most common non-communicable diseases worldwide and rises an interest for many researchers. New studies emerge revealing an imbalanced immune system that aggravates upon obesity and affects multiple immune processes, as well as increasing interest in studying obstructive sleep apnea syndrome resulting in tissue hypoxia, thereby increasing a risk of cardiovascular diseases. Our study allowed to detect metabolic syndrome in 89% of obese patients (groups 1 and 2) and 25% of adolescents with normal body weight (control group 2). We analyzed the complement components and circulating immune complexes of various fractions and revealed positive dynamics of the examined parameters due to combination therapy with the anti-oxidant Mexidol and hyperbaric oxygenation, which may indicate that oxygen-dependent neuroimmune mechanisms might be involved in the pathogenesis of metabolic syndrome in obesity. Such systemic activation of regulatory mechanisms for maintaining homeostasis is necessary for formation of biologically active thymusderived serum factor ensuring lymphocyte differentiation, i.e. pathogenetic therapy corrects dysregulatory impact of traditional therapy for obesity and optimizes immune responses. During the study we observed that the combination treatment using Mexidol and HBO resulted in better recovery of clinical functions and immune responses, and that such therapy exerted a positive effect on dynamics of patient mental activity. We believe that such therapeutic effects were due to antioxidant and antihypoxic activity of the applied pharmacological drugs. We also found that obese children are featured with metabolic syndrome and predisposed to developing relevant complications. Hence, for early diagnostics of metabolic syndrome it is necessary to study children with normal body weight that will allow to diagnose metabolic changes at earlier stage, because changes in blood biochemical parameters such as triglycerides, very low-density lipoproteins, glycemia levels etc. occur long before initial changes in person appearance might emerge.

About the authors

G. N. Kukina

Main Bureau of Medical and Social Expertise in the Republic of Mordovia

Author for correspondence.
Email: forasmol@mail.ru

Kukina Galina N. - Pediatrician

430034, Republic of Mordovia, Saransk, Pushkin str., 68, apt 3

Phone: 7 (927) 195-11-77

Russian Federation

S. V. Kiryukhina

N. Ogarev National Research Mordovia State University

Email: fake@neicon.ru

PhD, MD (Medicine), Associate Professor, Professor, Department of Nervous Diseases and Psychiatry

Saransk, Republic of Mordovia

Russian Federation

D. A. Labunsky

N. Ogarev National Research Mordovia State University

Email: fake@neicon.ru

PhD (Medicine), Senior Lecturer, Department of Nervous Diseases and Psychiatry

Saransk, Republic of Mordovia

Russian Federation

V. A. Kolmykov

N. Ogarev National Research Mordovia State University

Email: fake@neicon.ru

Resident, Department of Nervous Diseases and Psychiatry

Saransk, Republic of Mordovia

Russian Federation

E. Yu. Yurasova

N. Ogarev National Research Mordovia State University

Email: fake@neicon.ru

Postgraduate Student, Department of Nervous Diseases and Psychiatry

Saransk, Republic of Mordovia

Russian Federation

E. V. Boyarkin

N. Ogarev National Research Mordovia State University

Email: fake@neicon.ru

Postgraduate Student, Department of General Surgery

Saransk, Republic of Mordovia

Russian Federation

References

  1. Балыкова Л.А., Гарина С.В., Назарова И.С., Белкина Н.Р., Сергеева Я.Р. Новый способ фармакологической коррекции постгипоксической кардиопатии новорожденных детей // Медицинский совет, 2018. № 8. С. 19-25. [Balykova L.A., Garina S.V., Nazarova I.S., Belkina N.R., Sergeeva Ya.R. New method of pharmacological correction of posthypoxic cardiopathy of newborn children. Meditsinskiy Sovet = Medical Council, 2018, Vol. 2, pp. 19-25. (In Russ.)]
  2. Бокарев И.Н. Метаболический синдром // Клиническая медицина, 2014. Т. 8. С. 71-76. [Bokarev I.N. Metabolic syndrome. Klinicheskaya meditsina = Clinical Medicine, 2014, Vol. 8, pp. 71-76. (In Russ.)]
  3. Гусова З.Р., Дзантиева Е.О., Хрипун И.А. Иммунологические аспекты ожирения // Альманах клинической медицины, 2015. № 1. C. 30-35. [Gusova Z.R., Dzantieva E.O., Khripun I.A. Immunological aspects of obesity. Almanakh klinicheskoy meditsiny = Almanac of Clinical Medicine, 2015, no. 1, pp. 30-35. (In Russ.)]
  4. Дедов И.И., Мельниченко Г.А. Ожирение: этиология, патогенез, клинические аспекты. М.: Медицинское информационное агентство, 2004. С. 16-20. [Dedov I.I., Melnichenko G.A. Obese: etiology, pathogenesis, clinical aspects]. Moscow: Medical News Agency, 2004, pp. 16-20.
  5. Кирюхина С.В. Экспериментально-клиническое обоснование патогенетической фармакологической коррекции обсессивно-фобических, конверсионных, астенических расстройств. Саранск, 2010. 40 с. [Kiryukhina S.V. Experimental and clinical justification of pathogenetic pharmacological correction of obsessivephobic, conversion, asthenic disorders. doctor of medical Sciences]. Saransk, 2010. 40 p.
  6. Национальные клинические рекомендации по диагностике, лечению и профилактике ожирения. 2017. 7 с. [National clinical guidelines for the diagnosis, treatment and prevention of obesity. 2017. 7 p.]
  7. Рекомендации Консенсуса российских экспертов по проблеме МС в Российской Федерации. 2010. C. 602-603. [Recommendations of the Consensus of Russian experts on the problem of MS IN the Russian Federation. 2010. pp. 602-603.
  8. Симбирцев А.С. Цитокины: классификация и биологические функции // Цитокины и воспаление, 2004. Т. 3, № 2. С. 16-23. [Simbirtsev A.S. Cytokines: classification and biological functions. Tsitokiny i vospalenie = Cytokines and Inflammation, 2004, Vol. 3, no. 2, pp. 16-23. (In Russ.)]
  9. Учамприна В.А., Романцова Т.И., Калашникова М.Ф. Комплексный подход к лечению метаболического синдрома // Ожирение и метаболизм, 2014. № 1. C. 32-36. [Uchamprina V.A., Romantsova T.I., Kalashnikova M.F. Complex approach to the treatment of metabolic syndrome. Ozhirenie i metabolizm = Obesity and Metabolism, 2014, no. 1, pp. 32-36. (In Russ.)]
  10. Labunskiy D., Kiryukhina S., Podsevatkin V. Hyperbaric oxygenation in treatment of tourette disease in comparison with medication therapy and their influence of immunity parameters. Eur. J. Neurol., 2019, Vol. 26, Suppl. 1, p. 949.
  11. Labunskiy D., Kiryukhina S., Podsevatkin V. Comparison of experimental cellular and molecular therapy in motor neuron disease. Eur. J. Neurol., 2019, Vol. 26, Suppl. 1, p. 829.
  12. Ferrari D., Pizzirani C., Adinilfi E. The P2X7 receptor: a key player in IL-1 processing and release. J. Immunol., 2006, Vol. 176, pp. 3877-3883.
  13. Fornari E., Maffeis C. Treatment of metabolic sindrome in children. Front. Endocrinol., 2019, Vol. 10, 702. doi: 10.3389/fendo.2019.00702.

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Copyright (c) 2020 Kukina G.N., Kiryukhina S.V., Labunsky D.A., Kolmykov V.A., Yurasova E.Y., Boyarkin E.V.

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